郑州大学学报（医学版）2017，Vol.52Issue(4)：438-442,5.DOI:10.13705/j.issn.1671-6825.2017.04.016
肝细胞癌组织中CD163的表达及其与血管、淋巴管生成的关系
Relationship of CD163 expression in hepatocellular carcinoma and the microvascular density and lymphatic vessel density
摘要
Abstract
Aim:To investigate the expression of CD163 protein in hepatocellular carcinoma(HCC).Methods: The expressions of CD163 and CD68 in 50 cases of primary HCC and matched peritumoral tissues were assessed by immunohistochemistry.CD34 and D2-40 were used to determine microvascular density(MVD) and lymphatic vessel density(LMVD),respectively.The relationship among CD163 expression with clinicopathological parameters,angiogenesis and lymphangiogenesis was analyzed.Results: The expression of CD163 in HCC tissue was significantly higher than that in peritumoral tissue(P<0.001),whereas the expression of CD68 in HCC tissue was significantly lower than that in peritumoral tissue(P<0.001).The positive expression rates of CD163 in macrophages and hepatoma cells accounted for 86.84% and 13.16%,respectively.The expression of CD163 in macrophages was related with hepatic cirrhosis and Edmondson grades(P<0.05).MVD and LMVD in high CD163-expression macrophage group were significantly higher than those in low CD163 expression macrophage group(P<0.001).Conclusion: The high expression of CD163 in macrophages may result in HCC progression,angiogenesis and lymphangiogenesis.关键词
CD163蛋白/CD34/D2-40/肝细胞癌/巨噬细胞Key words
CD163 protein/CD34/D2-40/hepatocellular carcinoma/macrophage分类
医药卫生引用本文复制引用
范奇超,范丽玲,杨剑鑫,林扬元,谢群..肝细胞癌组织中CD163的表达及其与血管、淋巴管生成的关系[J].郑州大学学报（医学版）,2017,52(4):438-442,5.基金项目
国家自然科学基金资助项目 81201670 （）
福建省自然科学基金项目 2017J01546 （）
莆田学院大学生创新创业训练计划 201511498007,201611498075,201611498008 （）
