郑州大学学报（医学版）2017，Vol.52Issue(4)：443-447,5.DOI:10.13705/j.issn.1671-6825.2017.04.017
Ⅳ期肺腺癌初诊时转移特征和生存分析
Features of initially presenting metastases and survival analysis in patients with stage Ⅳ lung adenocarcinoma
摘要
Abstract
Aim:To investigate the features of metastasis and clinical prognosis of patients with stage Ⅳ lung adenocarcinoma.Methods: The clinical data of 160 stage Ⅳ lung adenocarcinoma patients who were confirmed by pathology and whole body imaging were retrospectively reviewed.The survival rate was evaluated by Kaplan-Meier method.The prognosis were analyzed by Cox multivariate regression.Results: The most common sites of metastasis of lung adenocarcinoma were thoracic lymph nodes(83.8%),pulmonary/pulmonary lymphatics(63.1%),and pleural/pericardial(44.4%).The median survival time was 18.0 months.One-,two-and three-year survival rates were 64.6%,30.8%,and 20.1%,respectively.Univariate analysis showed that age,gender,tumor differentiation,thoracic lymph node metastasis status,pleural/pericardial metastasis,abdominal/pelvic metastasis,neck/axilla lymph node metastasis and TKI treatment had significant association with survival rate(P<0.05).Cox regression analysis showed that tumor differentiation(OR=2.648,95%CI=1.689-4.150),neck/axilla lymph node metastasis(OR=2.517,95%CI=1.358-4.664),abdomen/pelvis metastasis(OR=2.005,95%CI=1.203-3.342),thoracic lymph node metastasis status(OR=1.972,95%CI=1.067-3.645),TKI treatment(OR=1.694,95%CI=1.073-2.675),pleural/pericardial metastasis(OR=1.664,95%CI=1.050-2.637) were risk factors of prognosis of lung adenocarcinoma.Conclusion: Stage Ⅳ lung adenocarcinoma has a unique characteristic of metastasis.Tumor differentiation,neck/axilla lymph node metastasis,abdomen/pelvis metastasis,thoracic lymph node metastasis status,TKI treatment,pleural/pericardial metastasis status of stage Ⅳ lung adenocarcinoma may be prognostic indicators.关键词
肺腺癌/表皮生长因子受体/转移/生存分析Key words
lung adenocarcinoma/epidermal growth factor receptor/metastasis/survival analysis分类
医药卫生引用本文复制引用
李莎,吴静,胡亚辉,韩星敏,刘保平,李彦鹏..Ⅳ期肺腺癌初诊时转移特征和生存分析[J].郑州大学学报（医学版）,2017,52(4):443-447,5.基金项目
国家自然科学基金资助项目 U1404818 （）
