郑州大学学报（医学版）2017，Vol.52Issue(4)：452-456,5.DOI:10.13705/j.issn.1671-6825.2017.04.019
三七总皂苷在兔牙齿移动过程中对牙周组织转化生长因子-β1表达的影响
Influence of panax notoginseng saponins on expression of TGF-β1 in periodontal tissue of rabbits during teeth movement
摘要
Abstract
Aim:To investigate the effect of panax notoginseng saponins(PNS) on the expression of transforming growth factor-β1(TGF-β1) in periodontal tissue of rabbits during teeth movement.Methods: Sixteen 3-6-month-old male New Zealand rabbits were randomly allocated into two groups.The rabbits of PNS group were injected Xueshuantong and the rabbits of normal saline group were injected normal saline.Two tension springs with 80 g force were respectively applied between the first premolars and mandibular anterior teeth.After four weeks raising,the rabbits were sacrificed for the first premolars and periodontal tissues.Immunohistochemical staining and immunofluorescence staining were used to detect the expression of TGF-β1 in periodontal tissues of the teeth.At the day before modeling,and the 1st,2nd,3rd,and 4th week after modeling,blood samples were collected.The concentration of calciumion,phosphorus ion and alkaline phosphatase in serum was determined with automatic biochemical analyzer.Results: The concentration of alkaline phosphatase in serum in PNS group was higher than that in normal saline group(P<0.05).The expression of TGF-β1 of PNS group was stronger than normal saline group(P<0.05).Conclusion: Panax notoginseng saponins can promote the expression of TGF-β1 in the periodontal tissue of rabbits,and may play a certain role in promoting alveolar bone remodeling during teeth movement.关键词
三七总皂苷/兔/牙齿移动/牙周组织/转化生长因子-β1Key words
panax notoginseng saponins/rabbit/movement of teeth/periodontal tissue/TGF-β1分类
医药卫生引用本文复制引用
杨璐,王冠,黎婷,孙晋虎..三七总皂苷在兔牙齿移动过程中对牙周组织转化生长因子-β1表达的影响[J].郑州大学学报（医学版）,2017,52(4):452-456,5.基金项目
徐州市科技计划项目 KC14SH089 （）
