中医学报2017，Vol.32Issue(6)：989-991,995,4.DOI:10.16368/j.issn.1674-8999.2017.06.259
大叶紫珠对大鼠凝血功能及TXB2、6-keto-PGF1a表达的影响
Effect of Callicarlpa macrophylla Vahl Polysaccharides on Rat Coagulation Function, TXB2 and 6-keto-PGF1a Expression
摘要
Abstract
Objective:To investigate the hemostasis mechanism of Callicarlpa macrophylla Vahl on coagulation function,TXB2 and 6-keto-PGF1 a expression of rats.Methods:40 adult Wistar were randomly divided into control group (normal saline),Yunnan Baiyao group(0.9 g · kg-1),high dose Callicarlpa macrophylla Vahl group (10 g · kg-1,crude drug) and low dose Callicarlpa macrophylla Vahl group(5 g · kg-1,crude drug),continuous infusion for seven days.The effects of intragastric administration of Callicarlpa macrophylla Vahl on prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen concentration(FIB) as well as the levels of thromboxane B2(TXB2) and 6-keto-PGF1a in tat arterial blood were observed.Results:The Callicarlpa macrophylla Vahl decoction of the medium dose and high dose short apparently PT,TT and APTT and inmproved significantly FIB and TXB2 level and down-regulated 6-keto-PGF1a (P ＜ 0.05),Conclusion:The Callicarlpa macrophylla Vahl water decoction relates to activate intrinsic and entrinsic pathways to promote platelet aggregation platelet aggregation and modulate the level of TXB2 and 6-keto-PGF1 a.关键词
大叶紫珠/凝血功能/血栓素B2/6-酮-前列腺素F1a/大鼠Key words
Callicarlpa macrophylla Vahl/coagulation function/thromboxane B2/6-keto prostaglandin F1a分类
医药卫生引用本文复制引用
鲁合军..大叶紫珠对大鼠凝血功能及TXB2、6-keto-PGF1a表达的影响[J].中医学报,2017,32(6):989-991,995,4.基金项目
中国人民解放军全军后勤科研计划项目(CJN12J005) （CJN12J005）
