中国实用神经疾病杂志2017，Vol.20Issue(12)：5-7,3.
亚低温疗法联合依达拉奉对大鼠脑缺血再灌注损伤的保护作用
Protective effects of mild hypothermia combined with edaravone on rats with cerebral ischemic reperfusion injury
摘要
Abstract
Objective To observe protective effects of mild hypothermia combined with edaravone on rats with cerebral ischemic reperfusion injury.Methods Six hours after the establishment of focal cerebral ischemia by suture method,we performed reperfusion.And 24 hours after successful reperfusion injury,neurological functional deficits in sham-operation group,model group,edaravone group and mild hypothermia combined with edaravone group (combined group) were evaluated.Cerebral ischemic volume was measured by TCC staining and the number of positive Bax and Bcl-2 cells was tested by immunohistochemistry method.Results Compared with model group,edaravone group failed to reduce the infarct volume,but managed to decrease cell apoptosis via down-regulating Bax and up-regulating Bcl-2 for the purpose of protective effect.In addition,compared with model group and edaravone group,the combined group significantly lowered the degree of ischemic reperfusion injury and reduced infarct volume through the up-regulation of Bcl-2 and down-regulation of Bax.Conclusion Mild hypothermia combined with edaravone has good effects on rats with cerebral ischemic reperfusion injury.关键词
亚低温/脑缺血/依达拉奉/Bax/Bcl-2/大鼠Key words
Mild hypothermia/Cerebral ischemia/Edaravone/Bax/Bcl-2/Rats分类
医药卫生引用本文复制引用
吴达荣,曾志芬,陶恩祥..亚低温疗法联合依达拉奉对大鼠脑缺血再灌注损伤的保护作用[J].中国实用神经疾病杂志,2017,20(12):5-7,3.基金项目
深圳市卫生计生系统科研项目(项目编号:201402121) （项目编号:201402121）
深圳市龙岗区科技计划医疗卫生项目(项目编号:YLWS20140605174929210) （项目编号:YLWS20140605174929210）
