中国实用神经疾病杂志2017，Vol.20Issue(12)：11-14,4.
氟西汀对脑卒中后抑郁患者海马磁共振氢质子波谱影响的研究
Effect of fluoxetine on hydrogen proton magnetic resonance spectroscopy of hippocampus in patients with post-stroke depression
摘要
Abstract
Objective To explore the features of fluoxetine''s effect on hydrogen proton magnetic resonance spectroscopy(1H-MRS) of hippocampus in patients with post-stroke depression.Methods A total of 60 cases with post-stroke depression were collected as research group and were given fluoxetine for 8 weeks,and 62 cases with stroke were selected as control group.The levels of N-asparaginic acid (NAA),choline compound (Cho) and creatine compound (Cr) were detected by using 1H-MRS and then the ratios of NAA to Cr (NAA/Cr) and of Cho to Cr (Cho/Cr) were calculated.Results In left and right hippocampus before and after treatment,the NAA/Cr ratios in the research group (1.22±0.31 and 1.19±0.42,1.46±0.35 and 1.43±0.41) were higher than those in the control group (1.69±0.33 and 1.66±0.47),and the differences were significant (all P<0.05).Similarly,the Cho/Cr ratios of left and right hippocampus before and after treatment in the research group (1.58±0.39 and 1.59±0.46,1.55±0.43 and 1.53±0.42) showed higher ratio than those in the control group (1.26±0.42 and 1.31±0.47),and the differences were significant (all P<0.05).Additionally,in the research group,the NAA/Cr ratios in bilateral hippocampus after treatment (1.46±0.35 and 1.43±0.41) were higher than those before treatment (1.22±0.31 and 1.19±0.42),and the differences were significant (all P<0.05).Conclusion Fluoxetine may change the abnormal metabolism of bilateral hippocampal neurons in post-stroke depression patients.关键词
氟西汀/脑卒中后抑郁/磁共振波谱学/海马Key words
Fluoxetine/Post-stroke depression/Magnetic resonance spectroscopy/Hippocampus分类
医药卫生引用本文复制引用
郭志勇,谭西英,刘丽娇,王宇,任玉红,徐祥辉,李智花,张东卫..氟西汀对脑卒中后抑郁患者海马磁共振氢质子波谱影响的研究[J].中国实用神经疾病杂志,2017,20(12):11-14,4.基金项目
2014年度新乡市重点科技攻关计划项目(编号:ZG14007) （编号:ZG14007）
