中国实用神经疾病杂志2017，Vol.20Issue(12)：18-22,5.
CDH17和LRP1B基因多态性与一氧化碳中毒后迟发性脑病的相关性
Association of CDH17 and LRP1B gene polymorphisms with delayed encephalopathy after carbon monoxide poisoning
于建华 1王运良 2潘晓琳3
作者信息
- 1. 解放军第一四八中心医院检验科,山东 淄博 255300
- 2. 解放军第一四八中心医院神经内科,山东 淄博 255300
- 3. 解放军第一四八中心医院介入科,山东 淄博 255300
- 折叠
摘要
Abstract
Objective To investigate the association of CDH17 (cadherin-17) and LRP1B (low density lipoprotein receptor-related protein 1B) gene polymorphism with delayed encephalopathy after carbon monoxide poisoning.Methods The DEACMP patients were collected from June 2014 to June 2016.The patients were divided into DEACMP group and ACMP group.The CDH17 gene locus (rs2513796) and LRP1B locus (rs1541976,rs10183908) SNP typing were detected in two groups.Results LRP1B gene locus (rs1541976):the genotype distribution and allele frequency of the two groups were statistically significant (P<0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).The genotype distribution and allele frequency of the two groups were statistically significant (P<0.05).The genotype distribution of male and female patients in DEACMP group was statistically significant (P<0.05),but there was no significant difference in allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients in ACMP group (P>0.05).LRP1B gene locus (rs10183908):there was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in the genotype distribution between male and female patients in DEACMP group (P>0.05).The difference was statistically significant (P<0.05).There was no significant difference in the genotype distribution and gene frequency between male and female patients in ACMP group (P>0.05).CDH17 gene locus (rs2513796):there was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between the two groups (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients in DEACMP group (P>0.05).There was no significant difference in genotype distribution and allele frequency between male and female patients (P>0.05).Conclusion LRP1B gene locus (rs1541976) gene polymorphism is associated with DEACMP.The risk of DEACMP in male ACMP patients is increased,and the risk of A/C genotype is increased,and CAC genotype is prone to DEACMP.LRP1B gene locus (rs10183908) gene polymorphism was not associated with DEACMP.LRP1B gene polymorphism may have genetic susceptibility to sex in the pathogenesis of DEACMP.关键词
钙粘蛋白17/低密度脂蛋白受体相关蛋白1B/基因多态性/一氧化碳中毒/迟发型脑病Key words
CDH17/LRP1B/Gene polymorphism/Carbon monoxide poisoning/Delayed encephalopathy分类
医药卫生引用本文复制引用
于建华,王运良,潘晓琳..CDH17和LRP1B基因多态性与一氧化碳中毒后迟发性脑病的相关性[J].中国实用神经疾病杂志,2017,20(12):18-22,5.
