中国实用神经疾病杂志2017，Vol.20Issue(12)：39-41,3.
纳洛酮对急性重症非心源性脑梗死患者血浆BNP水平的影响
The effect of naloxone on plasma BNP level inpatients with severe acute non-cardiogenic cerebral infarction
杜家琇 1张淑玲 1白宏英 2刘海涛1
作者信息
- 1. 郑州人民医院,河南 郑州 450003
- 2. 郑州大学第二附属医院,河南 郑州 450014
- 折叠
摘要
Abstract
Objective To observe the effect of naloxone on plasma BNP level in patients with severe acute non-cardiogenic cerebral infarction (ANCCI) and to explore its protective mechanism.Methods We collected 116 cases with severe ANCCI (NIHSS≥8 scores,GCS ≤8 scores) in our study and randomly divided all cases into treatment group (n=58) and control group (n=58).Routine therapy was given for control group and combination of naloxone injection with routine therapy was given for treatment group.Plasma BNP level was detected on the 1st,3rd and 7th days and NIHSS and GCS were used to evaluate neurological function.Based on CT value we estimate the degree of brain edema.Results On the 3rd and 7th days the two groups showed high levels of plasma BNP,severe brain edema and serious neurological functional deficits.Compared with control group,treatment group presented lower level of BNP and less injury of brain edema and neurological function (P<0.05).Conclusion Naloxone can effectively improve the degree of neurological functional deficits and relieve brain edema.Its neuroprotective effect may be associated with down-regulation of plasma BNP level.关键词
纳洛酮/急性重症非心源性脑梗死/血浆BNP水平/NIHSS评分/GCS评分Key words
Naloxone/Severe acute non-cardiogenic cerebral infarction/Plasma BNP level/NIHSS scores/GCS scores分类
医药卫生引用本文复制引用
杜家琇,张淑玲,白宏英,刘海涛..纳洛酮对急性重症非心源性脑梗死患者血浆BNP水平的影响[J].中国实用神经疾病杂志,2017,20(12):39-41,3.
