湖南中医药大学学报2017，Vol.37Issue(8)：819-822,4.DOI:10.3969/j.issn.1674-070X.2017.08.002
毛冬青甲素对阿尔茨海默病模型大鼠学习记忆及海马神经元再生的影响
Effects of IlexoninA on Learning-Memory and Neuron Regeneration in the Hippocampal Neuron of Alzheimer's Disease Model Rats
摘要
Abstract
Objective To investigate the effects of Ilexonin A on neurological behavior and neuron regeneration in Alzheimer's disease (AD) model rats. Methods The 24 male SD rats were randomly divided into sham -opera-tion group, model group, Ilexonin A group, positive medicine group (donepezil). Aβ1-42 was injected into hippocampus CA1 re-gion of male SD rats and to establish Alzheimer's disease-like model, then from the 3th day after modeling, the Ilexonin A or Donepezil drug gavage lasted 4 weeks. The learning and memory abilities of the rats were assessed through Morris water maze behavioral test, and neuron proliferation was tested by Brdu label. The expression of proliferative cells in hippocampus tissues was determined by immunohitochemical method. The morphology of hippocampal pyramidal neuron were observed by Nissl stain-ing. Results Compared with the model group, the learning and memory of the rats in the drug treated groups sgnificantly in-creased (P<0.05) and the levels of neuron proliferation were increased in the hippocampal dentate gyrus (DG) region of Ilexonin A treated rats. Conclusion The Ilexonin A reatment can promote neuron regeneration in the hippocampal DG region, and im-prove the learning and memory ability of the Alzheimer's disease-like model rats.关键词
阿尔茨海默病/毛冬青甲素/学习记忆/神经元再生/Morris水迷宫实验Key words
Alzheimer's disease/Ilexonin A/learning and memory/neuron regeneration/Morris water maze test分类
医药卫生引用本文复制引用
马超,欧阳建,郑晓婷,李平,成绍武..毛冬青甲素对阿尔茨海默病模型大鼠学习记忆及海马神经元再生的影响[J].湖南中医药大学学报,2017,37(8):819-822,4.基金项目
国家级大学生创新创业训练计划项目(201510541008). （201510541008）
