湖南中医药大学学报2017，Vol.37Issue(8)：823-826,4.DOI:10.3969/j.issn.1674-070X.2017.08.003
三黄地榆散对多重耐药铜绿假单胞菌的抑制作用研究
Study on Inhibitory Effects of Multidrug Resistant Pseudomonas aeruginosa by Sanhuang Diyu Powder
摘要
Abstract
Objective To investigate inhibitory effects of muitidrug resistant Pseudomonas aeruginosa by Sanhuang Diyu powder and provide the basis for its clinical application. Methods TCM serum was used for antibacterial experiment in vitro of minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The scald model rats infected by muitidrug resistant Pseudomonas aeruginosa were given with gentamicin sulphate and Sanhuang Diyu powder by gavage, re-spectively. Both the normal group and the model group were given with same volume sterile normal saline by gavage. At the first 3, 7, 10 days after delivery, neutrophils and inflammatory factors were determined. Results The results of bacteriostasis experiment in vitro indicated that MIC and MBC of Sanhuang Diyu powder and gentamicin on muitidrug resistant Pseudomonas aeruginosa both were 512 μg/mL. The results of bacteriostasis experiment in vivo indicated that Sanhuang Diyu powder and gentamycin could significantly decrease the levels of serum WBC, IL-1β and TNF-α in model rats (P<0.05). Conclusion Sanhuang Diyu powder has inhibitory effect aganist the growth of muitidrug resistant Pseudomonas aeruginosa in rats, which maby related to its ability of regulating IL-1β and TNF-α.关键词
三黄地榆散/多重耐药铜绿假单胞菌/庆大霉素/抑菌Key words
Sanhuang Diyu powder/muitidrug resistant Pseudomonas aeruginosa/gentamicin/antimicrobial effect分类
医药卫生引用本文复制引用
张涛,伍君锋,肖新云,邓江艳,李帅东,刘俊青,蔡锐..三黄地榆散对多重耐药铜绿假单胞菌的抑制作用研究[J].湖南中医药大学学报,2017,37(8):823-826,4.基金项目
中西医结合基础湖南省"十二五"重点学科开放基金资助项目. （）
