海洋科学2017，Vol.41Issue(4)：51-56,6.DOI:10.11759/hykx20160311001
真空冷冻干燥微藻DHA油纳米乳工艺研究
Study on the vacuum freeze-drying process on microalgae oil nanoemulsion powder
摘要
Abstract
This study explores the vacuum freeze-drying process and characterizes microalgae DHA oil nanoemul-sion nanopowder, which is synthesized via ultrasonic. Result shows that the nanopowder is milky white and delicate with a constant dissolution rate of 10 s under the following conditions of the freeze-drying curve with oil phase to freeze-drying protective additive ratio of 1︰4 and glucose to mannitol ratio of 1︰3: (1) Pre-freezing at?40°C for 2 h under 0.2 mbar pressure; (2) Sublimation drying at –30℃ for 12 h under 0.2 mbar pressure followed by drying at –20℃ under 0.15 mbar pressure for 2.5 h; (3) Analytical drying at 25℃ for 3 h under 0.15 mbar pressure. Before freeze-drying, the particle size and polydispersity coefficient were (175.6±22.1) and (0.15±0.62) nm, respectively, and these values changed to (211.1±23.5) and (0.152±0.116), respectively, after freeze-drying, indicating that the difference between these values is small and in the range of nanometers. The vacuum freeze-drying technology not only ensures the long-term stability of DHA but also expands the scope of its application. DHA is therefore ex-pected to become a new nano-loaded drug system.关键词
微藻DHA油/纳米乳/真空冷冻干燥Key words
microalgae DHA oil/nanoemulsion/vacuum freeze-drying分类
轻工纺织引用本文复制引用
刘维维,吴鹏,王昭凯,林祥志..真空冷冻干燥微藻DHA油纳米乳工艺研究[J].海洋科学,2017,41(4):51-56,6.基金项目
厦门南方海洋研究中心项目 (No. 14CZP028HJ02) （No. 14CZP028HJ02）
国家自然科学基金项目(No. 41476148) （No. 41476148）
海洋经济创新发展区域示范项目(12PYY001SF08) [Xiamen Southern Oceaographic Center, No.14CZP028HJ02 （12PYY001SF08）
National Natural Science Foundation of China, No.41476148 （）
Marine economy innovation development area demonstration project, No.12PYY001SF08] （）
