解放军医学杂志2017，Vol.42Issue(7)：583-590,8.DOI:10.11855/j.issn.0577-7402.2017.07.02
库欣病患者脑功能改变及任务态功能磁共振成像研究
Characteristics of brain functional alterations and task functional magnetic resonance imaging in patients with Cushing's disease
摘要
Abstract
Objective To analyze the relationship between the brain functional alterations of patients with Cushing's disease (CD) and patients' mental symptom by applying the Evaluating Emotional Scales and task functional magnetic resonance imaging (Task fMRI).Methods Task fMRI was performed on 8 patients with diagnosed CD admitted in the Department of Endocrinology of Chinese PLA General Hospital from Nov. 2015 to Nov. 2016 and 21 healthy people with matched age, gender and education level as control. Meanwhile, Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), Positive and Negative Affective Scale (PANAS) and Cushing Quality of Life Scale (Cushing QOL) were obtained to assess the brain functions.Results Significant depression and anxiety were observed in patients with CD, and their positive affective score was substantially lower while the negative affective score was relatively higher compared with that in the controls. Task fMRI revealed that, when watching the positive pictures, the activation degree of left cerebellum and right postcentral gyrus weakened in CD patients than in the controls, and the positive correlations existed between the activation degree of left cerebellum and the 16 o'clock adrenocorticotrophic hormone (ACTH) level, and between the activation degree of right postcentral gyrus and the urinary free cortisol (UFC) level in CD patients. In contrast, when watching the negative pictures, the activation degree of left cerebellum, bilateral parahippocampal gyrus and left inferior frontal gyrus was weakened in CD patients than in the controls, and the activation degree of left cerebellum was negatively correlated to the 0 o'clock cortisol level and SAS score, but is positively correlated to the UFC level. When watching the neutral pictures, the activation degree of left cerebellum and left parahippocampal gyrus was weakened in CD patients than in the controls.Conclusions CD patients may have impaired brain function with depression and anxiety mental symptoms. By Task fMRI, it can be found that the weakened activation degree of left inferior frontal gyrus, right postcentral gyrus, bilateral parahippocampal gyrus and left cerebellum may be related to CD patients' mental symptoms.关键词
库欣病/精神障碍/脑功能/任务态功能磁共振成像Key words
Cushing disease/mental disorders/brain function/task functional magnetic resonance imaging分类
医药卫生引用本文复制引用
刘丹丹,金楠,杨丽娟,巴建明,吕朝晖,母义明,单保慈,马林,窦京涛,周薇,李盼龙,李乐乐,陈微,谷伟军,裴育,杜锦,臧丽..库欣病患者脑功能改变及任务态功能磁共振成像研究[J].解放军医学杂志,2017,42(7):583-590,8.基金项目
This work was supported by the National Natural Science Foundation of China (81171319), the "Wonderful Tactics of Diseases"Project of PLA General Hospital (MJ201401), and the "Hundreds of Famous Doctors" Project of PLA General Hospital (MY201401)国家自然科学基金(81171319) （81171319）
解放军总医院"百病妙诀"扶植项目(MJ201401) （MJ201401）
解放军总医院"百位名医"项目(MY201401) （MY201401）
