解放军医学杂志2017，Vol.42Issue(7)：603-607,5.DOI:10.11855/j.issn.0577-7402.2017.07.05
人白血病相关蛋白16在垂体泌乳素腺瘤患者中的表达及其与雌激素受体α表达水平的相关性分析
Expression of leukemia-related protein 16 and the correlation to the estrogen receptor α levels in patients with prolactin adenomas
摘要
Abstract
Objective To study the expression of leukemia-related protein 16 (LRP16) in human pituitary prolactin adenomas (PRL adenomas), and the relationship between LRP16 and estrogen receptorα (ERα).Methods From October 2009 to September 2014, thirty-one adult patients diagnosed and pathologically confirmed as pituitary prolactin (PRL) adenomas (observation group) and 22 pituitary non-PRL adenomas (control group) in the Chinese PLA General Hospital were verified by the pathological examination. Immunohistochemical method was used to detect the expression levels of LRP16, PRL and ERα.Results Of the patients in observation group, those aged under 30 were predominantly females, while male patients were more common in those aged over 30. LRP16 positively existed in 26 cases (83.9%, 26/31), and ERα was positive in 28 cases (90.3%, 28/31), the both ratios were significantly higher than those in control group. ERα and LRP16 increased synchronously both in expressive content and intensity, showing a certain positive correlation between them.Conclusions Higher body mass index may be a high-risk factor badly affected the occurrence, development and prognosis in male patients with pituitary PRL; LRP16 may take part in the proliferation and formation of pituitary PRL adenomas through ERα.关键词
垂体泌乳素腺瘤/雌激素受体α/白血病相关蛋白16/泌乳素Key words
pituitary prolactin adenoma/estrogen receptorα/leukemia-related protein 16/prolactin分类
医药卫生引用本文复制引用
苏星,王安平,宋志刚,赵坤,郭清华,母义明..人白血病相关蛋白16在垂体泌乳素腺瘤患者中的表达及其与雌激素受体α表达水平的相关性分析[J].解放军医学杂志,2017,42(7):603-607,5.基金项目
This work was supported by the National Natural Science Foundation of China (81270866, 81570705) 国家自然科学基金(81270866,81570705) （81270866, 81570705）
