吉林中医药2017，Vol.37Issue(7)：670-673,4.DOI:10.13463/j.cnki.jlzyy.2017.07.007
利巴韦林与热毒宁治疗小儿急性上呼吸道感染
Ribavirin and Reduning in the treatment of children acute upper respiratory tract infection
摘要
Abstract
Objective To study the clinical effects of Ribavirin and Reduning in the treatment of children acute upper respiratory tract infection. Methods 90 cases of children with acute upper respiratory tract infection were randomly divided into control group and observation group by number table method, 45 cases in each group. 2 groups were given conventional treatment, the control group on the basis of the conventional treatment combined with ribavirin, 10 mg/kg of ribavirin and 100 mL of 5% glucose solution, intravenous drip, 1 times a day. Observation group were treated with 0.6 m/kg Reduning injection (ingredients including artemisinin, honeysuckle, gardenia, accessories is polysorbate) and100 mL of 5% glucose solution, intravenous drip, 1 times a day, three days is a course of treatment. The main symptoms, changes of body temperature and white blood cell, the incidence of adverse reactions was compared of the two groups. Results The control group of the cooling time, check discharge time, pharyngeal swelling time, cough disappeared time was (3.45±1.23) d, (3.39±1.11) d, (3.41±1.15) d, (3.39±1.08) d,the observation group the cooling time, check discharge time, pharyngeal swelling time, cough disappeared time was (2.25±1.09) d, (2.21±0.09) d, (2.27±1.12) d, (2.35±1.14) d, the observation group compared with the control group, the cooling time, check discharge time, pharyngeal swelling time, cough disappeared time was shortened, the difference was statistically significant (P<0.05). The patients in the control group after treatment, the body temperature, white blood cell count respectively (37.03±0.99)oC, (10.49±2.33)×109, patients in the observation group after treatment of body temperature, white blood cell count respectively (36.28±0.45)oC, (9.79±1.68)×109, the 2 groups were compared before and after treatment, body temperature and white blood cell count decreased, the observation group compared with the control group improved more significantly, the difference was statistically significant (P<0.05). Control group on the nausea and vomiting, abdominal discomfort, diarrhea, skin rash rates were 11.11%, 13.33%, 8.99%, 13.33%, observation group of nausea and vomiting, abdominal discomfort, diarrhea, skin rash on the incidence of 2.22%, 4.44%, 2.22% and 2.22% respectively, on the observation group compared with control group, nausea and vomiting, abdominal discomfort, have a lower incidence of diarrhea, skin rash, statistically significant difference (P<0.05). Conclusion The clinical curative effect of Reduning treatment of children with acute upper respiratory tract infection significantly than ribavirin, which can speed up the time of symptoms reduce the incidence of adverse reactions.关键词
利巴韦林/热毒宁/小儿/急性上呼吸道感染/疏散风热/清热解毒/凉血泻火Key words
ribavirin/Reduning/children acute upper respiratory tract infection/evacuation of wind heat/clearing away heat and toxic material/cooling blood to relieve fire分类
医药卫生引用本文复制引用
张帆..利巴韦林与热毒宁治疗小儿急性上呼吸道感染[J].吉林中医药,2017,37(7):670-673,4.基金项目
湖北省科技攻关课题(2015AA301C10). （2015AA301C10）
