解放军医学院学报2017，Vol.38Issue(6)：493-496,4.DOI:10.3969/j.issn.2095-5227.2017.06.001
预防性脑照射与替莫唑胺单药预防小细胞肺癌脑转移的比较
Preventive effect of temozolomide versus traditional prophylactic cranial irradiation on brain metastases from small-cell lung cancer
摘要
Abstract
Objective Our study aimed to compare the effect of prophylactic cranial irradiation (PCI) or temozolomide (TMZ) in preventing brain metastases from small cell lung cancer and analyze their safety. Methods This trial recruited 52 patients in Chinese PLA General Hospital from Jan 2008 to Dec 2014. All patients were divided into PCI group(26) and TMZ group(26). In PCI group, patients received 25 Gy/10 F prophylactic cranial irradiation after first-line therapy, while in TMZ group patients received oral TMZ (100-150 mg/m2; d1-d5/28 d). One year brain metastases positive rate, cranial-progression-free survival, overall survival and progression free survival were analyzed, and adverse reactions were recorded. Results There were no significant difference between PCI group and TMZ group in 1 year brain metastases positive rate (19.23% vs 30.77%, P > 0.05), cranial-progression-free survival (16 months vs 15 months, P > 0.05), PFS (7 months vs 8 months, P > 0.05) and OS (25 months vs 18 months, P > 0.05). Acute adverse events in PCI group were dizziness and nausea, and some patients had long-term adverse reactions in nervous system. Patients received temozolomide had moderate hematologic toxicities and gastrointestinal adverse reactions, and can be tolerated. Conclusion Temozolomide is well tolerated and as good as traditional PCI in preventing brain metastases. Though temozolomide was inferior to PCI in prolonging OS, there was no statistically significant difference.关键词
小细胞肺癌/脑转移/预防性全脑照射/替莫唑胺Key words
small cell lung cancer/brain metastasis/prophylactic cranial irradiation/temozolomide分类
医药卫生引用本文复制引用
邵蔚,马俊勋,陶海涛,王琪,胡毅..预防性脑照射与替莫唑胺单药预防小细胞肺癌脑转移的比较[J].解放军医学院学报,2017,38(6):493-496,4.基金项目
部委级资助项目 （）
军队保健专项课题 (14BJZ04) Supported by the Special Project for Healthcare of PLA(14BJZ04) （14BJZ04）
