解放军医学院学报2017，Vol.38Issue(6)：509-511,515,4.DOI:10.3969/j.issn.2095-5227.2017.06.005
Ki67、胎盘碱性磷酸酶在细胞角蛋白对颅内生殖细胞瘤和垂体瘤鉴别诊断中的价值
Value of Ki67, PLAP and CK in differential diagnosis of germinomas and pituitary adenomas
刘红艳 1谷伟军 1母义明1
作者信息
- 1. 解放军总医院 内分泌科,北京 100853
- 折叠
摘要
Abstract
Objective To investigate the expressions of Ki67, placental alkaline phosphatase (PLAP), cytokeratin (CK)and their diagnostic values to germinomas and pituitary adenomas. Methods Thirty-six patients with germinomas (experiment group) and 40 patients with pituitary adenomas (control group) were selected. The expression of Ki67, PLAP and CK were detected by immunohistochemical assay, and the difference of their expression in two tumors was analyzed. Results The positive rates of Ki67, PLAP in germinomas were significantly higher than those in pituitary adenomas (Ki67: 95.2% vs 47.6%, P=0.001; PLAP: 88.6% vs 16.7%, P < 0.001). The positive rate of CK in germinomas was 27.8% (5/18), which was significantly lower than that in pituitary adenomas of 82.6% (19/23) (x2=12.508, P < 0.001). Conclusion Ki67, PLAP and CK can serve as auxiliary biological indicators in differential diagnosis of germinomas and pituitary adenomas.关键词
颅内生殖细胞瘤/垂体瘤/Ki67/胎盘碱性磷酸酶/细胞角蛋白Key words
intracranial germinomas/pituitary adenomas/Ki67/placental alkaline phosphatase/cytokeratin分类
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刘红艳,谷伟军,母义明..Ki67、胎盘碱性磷酸酶在细胞角蛋白对颅内生殖细胞瘤和垂体瘤鉴别诊断中的价值[J].解放军医学院学报,2017,38(6):509-511,515,4.
