摘要
Abstract
Objective To study the influence of low dose dexmedetomidine(DEX) on sedation depth,hemodynamic parameters during surgery and oxidative stress postoperation in cesarean section women.Methods 118 cases of cesarean section women in our hospital during June 2014 to June 2016 were collected and divided into observation group(n=59) and control group(n=59) according to random number table.Dexmedetomidine 0.4 μg/kg was intravenously infused over 10 min after fetal disengagement and Omphalotomy in observation group and the equal volume of normal Saline was given in control group.Amsay sedation score was evacuated at Dexmedetomidine before administration(T0),after administration of 10 min(T1),abdominal wall suture complete(T2),respiratory metabolism indices were tested by cardiopulmonary functioninstrument,hemodynamic parameters were readed on ECG monitor,serum oxidative stress levels were detected by automatic biochemical analyzer.Results At T1,T2 time point,Ramsay sedation score values were higher in observation group than those in control group;respiratory metabolism indices such as respiratory quotient(RQ),Oxygen consumption(VO2),carbon dioxide emission(VCO2) were lower in observation group than those in control group;hemodynamic parameters such as systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR) were lower in observation group than those in control group,the difference was statistically significant(P<0.05).6,12,24 h after cesarean section,serum oxidation indices such as malondialdehyde(MDA),lipid peroxide(LHP) and advanced oxidation protein products(AOPP) in observation group were lower than in control group,antioxidation indices such as Glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC) levels in observation group were higher than those in control group,the difference was statistically significant(P<0.05).Conclusion Low dose dexmedetomidine can increase sedation depth,stable hemodynamic parameters during cesarean section in parturients,reduce oxidative stress injury after operation.关键词
剖宫产术/右美托咪定/清醒镇静/血流动力学/氧化应激Key words
cesarean section/dexmedetomidine/conscious sedation/hemodynamics/oxidative stress
