检验医学与临床2017，Vol.14Issue(14)：2045-2047,3.DOI:10.3969/j.issn.1672-9455.2017.14.015
中晚期非小细胞肺癌化疗前后二乙酰精胺的变化
Changes of diacetylspermidine before and after chemotherapy in advanced non-small cell lung cancer
贺旭东 1刘峰 2宫晓丽 2周占文3
作者信息
- 1. 辽宁中医药大学附属医院临床检验中心,沈阳 100032
- 2. 辽宁迈迪生物科技有限公司技术部,辽宁本溪 117004
- 3. 辽宁中医药大学附属医院医学影像中心,沈阳 100032
- 折叠
摘要
Abstract
Objective This study was designed to research the reliability to use urine diacetylspermine(DAS) in the assessment of chemotherapy effect for non-small cell lung cancer(NSCLC) patients.Methods Seventy eight advanced NSCLC patients who received initialtreatment were selected in this study.Platinum-based doublet chemotherapy was applied for two cycles therapy,with a week for each cycle.Three weeks after each therapy cycle,therapy effects were assessed and urine DAS content(modified with urine creatinine,Ucr) was determined.Results All of the 78 patients finished the study.The disease control rate(DCR) in first cycle therapy was 75.64%,and 87.18% in second cycle therapy.Urine DAS in first-chemotherapy patients was significantly decreased than in pre-chemotherapy[(1.83±0.30) mmol/mL/g Ucr vs.(2.17±0.36)mmoL/ mL/g Ucr,P<0.01].Urine DAS content in second cycle chemotherapy patients continued to decrease notably compared with that in first cycle therapy[(1.35±0.19) mmol/mL/g Ucr vs.(1.83±0.30) mmol/mL/g Ucr,P<0.01].Urine DAS was markably decreased in curative patients in first cycle therapy than in patients without curative effects[(1.21±0.21)mmol/mL/g Ucr vs.(1.62±0.37) mmol/mL/g Ucr,P<0.01].In second cycle therapy,urine DAS content in curative patients was also decreased notably compared with that in patients without curative effects[(1.62±0.37)mmol/mL/g Ucr vs.(2.25±0.35) mmol/mL/g Ucr,P<0.01].No significant difference was found between no-curative patients in two cycle chemotherapy(P>0.05).Conclusion Chemotherapy effect correlates well with urine DAS content in advanced NSCLC patients.Urine DAS content can be used as a biomarker to monitor curative effect of chemotherapy for advanced NSCLC patients.关键词
二乙酰精胺/非小细胞肺癌/化疗疗效Key words
diacetylspermine/non-small cell lung cancer/chemotherapy effect引用本文复制引用
贺旭东,刘峰,宫晓丽,周占文..中晚期非小细胞肺癌化疗前后二乙酰精胺的变化[J].检验医学与临床,2017,14(14):2045-2047,3.
