检验医学与临床2017，Vol.14Issue(14)：2067-2070,4.DOI:10.3969/j.issn.1672-9455.2017.14.023
细胞因子与非小细胞肺癌术后复发的相关性
Correlation between cytokines and non-small cell lung cancer recurrence
官廷华 1俞永康 1姜建青 1毛平1
作者信息
- 1. 成都军区总医院胸外科,成都 610083
- 折叠
摘要
Abstract
Objective To investigate the relationship between the expression of-3(PTX-3),keratin 19(CYFRA21-1) and the expression of thyroid transcription factor(TTF-1) and early postoperative recurrence of non-small cell lung cancer.Methods A total of 72 consecutive NSCLC patients were followed up for two years,according to the follow-up results were divided into relapse group(n=26) and non recurrence group(n=46).All patients were performed before and after operation in January and March to detect the serum PTX-3,CYFRA21-1 and TTF-1 concentration.Results The recurrence group were seen 3 months after surgery,serum PTX-3,CYFRA21-1 and TTF-1 levels were significantly increased(P<0.05).The postoperative recurrence in January.Serum PTX-3 and TTF-1 levels were significantly higher than those in non recurrence group(P<0.05);postoperative recurrence 3 months group serum PTX-3,CYFRA21-1 and TTF-1 levels were significantly higher than those in non the recurrence group(P<0.05).ROC curve analysis indicated that serum 3 months after surgery(AUC=0.823) and the Δ1(AUC=0.863) PTX-3 level for NSCLC in predicting postoperative recurrence.The maximum value of the correlation analysis indicated that PTX-3(3 months after operation,delta Δ1 and delta Δ2) CYFRA21-1 and TTF-1 surgery(3 months after surgery and delta Δ1) were correlated to NSCLC in patients after operation.Conclusion The monitoring of PTX-3,CYFRA21-1 and TTF-1 after operation in patients with NSCLC may contribute to early warning of tumor recurrence.关键词
非小细胞肺癌/穿透素3/角化素蛋白片段19/甲状腺转录因子-1Key words
non-small cell lung cancer/PTX-3/CYFRA21-1/TTF-1引用本文复制引用
官廷华,俞永康,姜建青,毛平..细胞因子与非小细胞肺癌术后复发的相关性[J].检验医学与临床,2017,14(14):2067-2070,4.
