摘要
Abstract
Objective To analyze the relationship between the serun levels of homocysteine(Hcy),cystatin C(Cys C),high-sensitivity C reactive protein(hs-CRP) and diabetic peripheral neuropathy.Methods Fifty cases of patients with single diabetes and fifty-five cases of patients with diabetic peripheral neuropathy were respectively selected as the diabetic group and peripheral neuropathy group,and another sixty cases of healthy volunteers were noted as the normal control group.The serum levels of Hcy,Cys C,hs-CRP were detected and compared among the groups,then the nerve electrophysiological examination was conducted.The relationships between the levels of serum Hcy,Cys C,hs-CRP in patients with diabetic peripheral neuropathy and the examination results were analyzed by Pearson linear correlation model.Results The levels of serum Hcy and hs-CRP in the peripheral neuropathy group and the diabetic group were far higher than those in the normal control group(P<0.05),which in the diabetic group were far higher than those in the normal control group(P<0.05).The difference in the levels of serum Cys C was not statistically significant(P>0.05),which were significantly lower than that in the peripheral neuropathy group(P<0.05).The levels of median nerve MCV,the gastrocnemius nerve SCV,motor conduction amplitude,median nerve F wave latency in the diabetic group and peripheral neuropathy group were far lower than those in the normal control group(P<0.05),which in the peripheral neuropathy group were far lower than those in the diabetic group(P<0.05).There were obviously negative relationships between the levels of serum Hcy and hs-CRP and the indexes of nerve electrophysiological examination in patients with diabetic peripheral neuropathy(r<0,P<0.05),while there was no obvious relationship between the level of serum Cys C and the indexes(P>0.05).Conclusion There are negative relationships beyween the levels of serum Hcy and hs-CRP and the indexes of median nerve MCV,the gastrocnemius nerve SCV,motor conduction amplitude,median nerve F wave latency in patients with diabetic peripheral neuropathy.关键词
同型半胱氨酸/胱抑素C/超敏C反应蛋白/糖尿病周围神经病变Key words
Homocysteine/Cystatin C/High-sensitivity C reactive protein/diabetic peripheral neuropathy
