摘要
Abstract
Objective To explore insulin pump intensive treatment on the influence of the first diagnosis in patients with type 2 diabetes oxidative stress level.Methods 70 patients with newly diagnosed type 2 diabetes mellitus were selected and randomly divided into treatment group(n=35)and control group(n=35).Treatment group patients was treated with insulin pump,the control group was used multiple subcutaneous insulin injections as control,treatment time was 2 weeks.Observed and compared the two groups of patients with fasting insulin,insulin,2 hours after meal glycosylated hemoglobin and superoxide dismutase,reduced glutathione and blood eight different changes of the prostaglandin F2α.Results After two weeks of insulin therapy,all patients on an empty stomach,2 hours after the meal,insulin and glycosylated hemoglobin had certain degree of decline,the difference was statistically significant (P<0.05);Superoxide dismutase,reduced glutathione and blood treatment group of eight different prostaglandins F2 alpha variation were better than those of control group,the difference was statistically significant (P<0.05).Conclusion Insulin has good curative effect in patients with type 2 diabetes,and insulin pump short-term intensive therapy can improve oxidative stress at the same time in the stability of hypoglycemic and reduce inflammation.关键词
2型糖尿病/胰岛素泵/氧化应激Key words
type 2 diabetes/insulin pump/oxidative stress
