摘要
Abstract
Objective To observe the influence of different administration schemes of granisetron hydrochloride on PONV of elderly patients after laparoscopic surgery.Methods 117 cases of elderly patients treated with laparoscopic surgery in our hospital were selected as the study objects,and were divided into A group,B group and C group according to the random number table method,39 cases in each group.All the three groups were given uniform anesthesia,and A group were given intravenous administration of 5mg granisetron hydrochloride before 10min of anesthesia induction,B group were given immediate intravenous injection of 5mg hydrochloride at the end of surgery,and C group were respectively given 5mL Sodium Chloride Injection(concentration,0.9%) before 10min of anesthesia induction and at the end of surgery.The incidence rates of PONV at each moment,PONV degree at postoperative 24 h and adverse reactions were observed in the two groups.Results There were no significant differences in PONV incidences at postoperative 1h in the three groups(P>0.05).The incidence rates of 12 h,24 h,48 h in A group were significantly lower than those in B group and C group(P<0.05),which of B group were significantly lower than those in C group(P<0.05).PONV degree at postoperative 24 h in A group was better than that in B group and C group(P<0.05),and that of B group was better than that of C group(P<0.05).Adverse reactions in A group,B group,C group were 5.13%,10.26%,7.69% respectively,with statistically significant differences(P>0.05).Conclusion Granisetron hydrochloride can prevent PONV of elderly patients after laparoscopic surgery effectively,and the effect is better to give medicine before anesthesia.关键词
盐酸托烷司琼/腹腔镜手术/恶心/呕吐Key words
granisetron hydrochloride/laparoscopic surgery/nausea/vomit
