临床肝胆病杂志2017，Vol.33Issue(6)：1067-1074,8.DOI:10.3969/j.issn.1001-5256.2017.06.010
直接抗病毒药物治疗丙型肝炎的毒副作用、物相互作用及安全性
Adverse effects, drug interactions, and safety of direct-acting antiviral agents in treatment of hepatitis C
赵西太 1聂青和1
作者信息
- 1. 第四军医大学唐都医院传染病科,全军感染病诊疗中心,西安710038
- 折叠
摘要
Abstract
In recent years,direct-acting antiviral agents (DAAs) have achieved great success in the treatment of hepatitis C and have replaced interferon/ribavirin.However,since DAAs were launched not long ago,there lacks sufficient knowledge of their toxic and side effects,interactions with other drugs,and safety in patients complicated by other serious chronic diseases.The results of many large-scale clinical trials show that DAAs have good safety in different populations and serious toxic and side effects are rare,but drug interactions need to be taken seriously.The addition of ribavirin in DAA regimen or prolongation of DAA treatment does not increase patients' benefits and may cause more adverse events.Moreover,at the same time of DAA treatment,liver injury caused by HCV cannot be neglected,and continuous treatment should be given.关键词
肝炎,丙型/抗病毒药/药物相互作用Key words
hepatitis C/antiviral agents/drug interactions分类
医药卫生引用本文复制引用
赵西太,聂青和..直接抗病毒药物治疗丙型肝炎的毒副作用、物相互作用及安全性[J].临床肝胆病杂志,2017,33(6):1067-1074,8.
