临床肝胆病杂志2017，Vol.33Issue(6)：1106-1111,6.DOI:10.3969/j.issn.1001-5256.2017.06.018
应用判别分析法建立肝硬化患者营养风险筛查模型
A nutritional risk screening model for patients with liver cirrhosis established using discriminant analysis
摘要
Abstract
Objective To establish a nutritional risk screening model for patients with liver cirrhosis using discriminant analysis.Methods The clinical data of 273 patients with liver cirrhosis who were admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from August 2015 to March 2016 were collected.Body height,body weight,upper arm circumference,triceps skinfold thickness,subscapular skinfold thickness,and hand grip strength were measured and recorded,and then body mass index (BMI) and upper arm muscle circumference were calculated.Laboratory markers including liver function parameters,renal function parameters,and vitamins were measured.The patients were asked to complete Nutritional Risk Screening 2002 and Malnutrition Universal Screcning Tool (MUST),and a selfdeveloped nutritional risk screening pathway was used for nutritional risk classification.Observation scales of the four diagnostic methods in traditional Chinese medicine were used to collect patients' symptoms and signs.Continuous data were expressed as mean ± SD ((x) ± s);an analysis of variance was used for comparison between multiple groups,and the least significant difference t-test was used for further comparison between two groups.Discriminant analysis was used for model establishment,and cross validation was used for model verification.Resuits The nutritional risk screening pathway for patients with liver cirrhosis was used for the screening of respondents,and there were 49 patients (17.95％) in non-risk group,49 (17.95％) in possible-risk group,and 175 (64.10％) in risk group.The distance criterion function was used to establish the nutritional risk screening model for patients with liver cirrhosis:D1 =-11.885 + 0.310 × BMI + 0.150 ×MAC + 0.005 x P-Alb-0.001 x Vit B12 + 0.103 x Vit D-0.89 x ascites-0.404 x weakness-0.560 × hypochondriac pain + 0.035 x dysphoria with feverish sensation (note:if a patient has ascites,weakness,hypochondriac pain,or dysphoria with feverish sensation,this index equals 1,and otherwise it equals 0).Cross validation showed that the probability of misclassification of the this model was 10％.Conclusion The established screening model may provide a reference for chnical nutritional risk screening in patients with liver cirrhosis.关键词
肝硬化/营养不良/判别分析Key words
liver cirrhosis/malnutrition/discriminant analysis分类
医药卫生引用本文复制引用
诸炳骅,赵长青,周扬,徐列明..应用判别分析法建立肝硬化患者营养风险筛查模型[J].临床肝胆病杂志,2017,33(6):1106-1111,6.基金项目
国家基础科学人才培养基金项目(J1103607) （J1103607）
