临床肝胆病杂志2017，Vol.33Issue(7)：1262-1265,4.DOI:10.3969/j.issn.1001-5256.2017.07.011
肝细胞癌的血清学诊断——挑战与希望同在
Serological diagnosis of hepatocellular carcinoma: challenges and opportunities
鲁凤民1
作者信息
- 1. 北京大学基础医学院 病原生物学系,北京 100191
- 折叠
摘要
Abstract
Serological markers have the features of noninvasiveness and simple operation and thus have become a research hotspot in the diagnosis of hepatocellular carcinoma.This article briefly introduces the role of the conventional serological marker alpha-fetoprotein (AFP) in assisting the diagnosis and predicting the prognosis of HBV-related liver cancer, as well as the clinical value of new markers such as alpha-fetoprotein-L3 and abnormal prothrombin/des-γ-carboxy prothrombin.Based on literature review, the possibility of serum Golgi protein 73 used for laboratory auxiliary diagnosis of hepatocellular carcinoma has been denied.The results of the author′s experiment suggest that serum GP73 measurement can be used as a laboratory diagnostic index for progressive liver fibrosis and liver cirrhosis.关键词
癌,肝细胞/肝硬化/甲胎蛋白类/甲胎蛋白异质体/异常凝血酶原/高尔基体蛋白73Key words
carcinoma,hepatocellular/liver cirrhosis/alpha-fetoproteins/alpha-fetoprotein-L3/des-gamma-carboxynprothrombin/Golgi protein 73分类
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鲁凤民..肝细胞癌的血清学诊断——挑战与希望同在[J].临床肝胆病杂志,2017,33(7):1262-1265,4.
