临床肝胆病杂志2017，Vol.33Issue(7)：1369-1372,4.DOI:10.3969/j.issn.1001-5256.2017.07.037
磷脂酰肌醇蛋白聚糖3在肝癌治疗中的应用进展
Advances in the application of GPC3 in treatment of liver cancer
摘要
Abstract
Liver cancer is one of the most common malignant tumors in the world, and traditional liver cancer treatment methods have their own limitations.Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan and is involved in the regulation of individual development and cell proliferation and differentiation.It is also a hepatoma-specific carcinoembryonic antigen.The mechanism of action of GPC3 in the development and progression of liver cancer has become a hot research topic.GPC3 not only has a unique value in the diagnosis of liver cancer, but also plays an important role in the treatment of liver cancer.This article also introduces the application of GPC3-derived tumor vaccines, GPC3 antibodies, GPC3 gene therapy, and targeted therapy and brings new ideas for the treatment of liver cancer.关键词
肝肿瘤/磷脂酰肌醇蛋白聚糖类/治疗/综述Key words
liver neoplasms/glypicans/therapy/review分类
医药卫生引用本文复制引用
任志忠,张跃伟..磷脂酰肌醇蛋白聚糖3在肝癌治疗中的应用进展[J].临床肝胆病杂志,2017,33(7):1369-1372,4.基金项目
国家自然科学基金项目(81571783) （81571783）
