临床口腔医学杂志2017，Vol.33Issue(7)：387-390,4.DOI:10.3969/j.issn.1003-1634.2017.07.002
大鼠颅骨临界骨缺损Bio-Oss与Bio-Gide干预下新骨与血管形成的研究
The relationship between osteogenesis and angiogenesis under interference of Bio-Oss or Bio-Gide with natural healing progress during rat skull critical bone defect.
石磊 1曹岑 2黄颖 3邓旭亮1
作者信息
- 1. 北京大学口腔医院修复科 北京 100081
- 2. 华中科技大学同济医学院附属同济医院口腔医学中心 湖北 武汉 430030
- 3. 北京大学口腔医院特诊科 北京 100081
- 折叠
摘要
Abstract
Objective: This manuscript aimed to compare the difference in sequential and spatial distribution of osteogenesis and angiogenesis between cranial critical-sized defect healing treated with or without bone-substitute materials.Methods:Rats cranial critical-sized defect (CSD) treated with bone-substitute materials (Bio-Oss or Bio-Gide) were regarded as test groups (Bio-Oss group and Bio-Gide group,respectively) and CSD treated without bone-substitute materials was regarded as control group (Natural healing group).Micro-CT and histology analysis were taken to observe new bone formation,while angiography with Microfil? was used to observe angiogenesis in these groups.Results:Both of osteogenesis and angiogenesis were increased in these groups (Natural healing group,Bio-Oss group and Bio-Gide group) with the time-lapse of operation.However,the sequential and spatial distribution of osteogenesis and angiogenesis was different among these groups.The bone and blood vessels regenerated from the periphery to the center of the defect during natural healing.The bone and blood vessels regenerated around the defect and in the area around Bio-Oss.The bone and blood vessels diffusely regenerated in the whole defect area of Bio-Gide group.Conclusion:Osteogenesis is closely related to angiogenesis during bone defect healing.The administration of bone-substitute materials affected the quantity of new bone formation and the distribution of new blood vessels.关键词
骨缺损修复/新骨形成/新生血管形成/体内研究Key words
Bone defect repair/Osteogenesis/Angiogenesis/In vivo study 分类
医药卫生引用本文复制引用
石磊,曹岑,黄颖,邓旭亮..大鼠颅骨临界骨缺损Bio-Oss与Bio-Gide干预下新骨与血管形成的研究[J].临床口腔医学杂志,2017,33(7):387-390,4.
