临床神经病学杂志2017，Vol.30Issue(3)：161-165,5.
脑白质损害对急性缺血性卒中患者短期功能结局的影响
Effect of white matter lesion severity on short-term functional outcome in the patients with acute ischemic stroke
摘要
Abstract
Objective To explore the effect of white matter lesion severity on short-term functional outcome in the patients with acute ischemic stroke.Methods A total of 402 patients with first acute ischemic stroke admitted from August 2013 to January 2016 were enrolled in the study and all patients underwent brain MRI, severity of white matter lesions was assessed by age related white matter changes (ARWMC) scale.Functional outcome was assessed by mRS at 3 months after onset.Multiple logistic regression models were used to identify the independent risk factors.Results Univariable analysis revealed that age, NIHSS, coronary heart disease, TOAST, triglyceride, very low density lipoprotein, ARWMC and frontal lobe scores, parietal-occipital lobe scores had significant difference between favorable prognosis group and unfavorable prognosis group (allP<0.05).The result of logistic regression analysis indicated that age (OR=1.051, P<0.01), NIHSS (OR=1.597, P<0.05) were independent risk factors of 3-month prognosis when the severity of white matter lesions was not considered.After adjustment for age and NIHSS score, ARWMC(OR=1.118, P=0.008)and frontal lobe scores(OR=1.223,P=0.017)were independent risk factors of 3-month prognosis when white matter lesions went into the regression equation.Spearman rank correlation showed that the severity of white matter lesions was slightly associated with 3-month mRS score (r=0.21,P<0.05).Conclusions The severity and locations of white matter lesions in the first acute ischemic stroke patients may predict the 3-month function outcome.The effect of NIHSS, ARWMC and age on prediction of prognosis are independent and decreases in turn.关键词
缺血性卒中/功能结局/MRI/白质损害Key words
ischemic stroke/functional outcome/MRI/white matter lesions分类
医药卫生引用本文复制引用
韩凝,贾阳娟,王美蓉,贾艳丽,赵景茹,肖向建,王建华..脑白质损害对急性缺血性卒中患者短期功能结局的影响[J].临床神经病学杂志,2017,30(3):161-165,5.基金项目
河北省重大医学科研课题(zd2013001) （zd2013001）
河北省科技支撑计划项目(12276104D-18) （12276104D-18）
