临床神经病学杂志2017，Vol.30Issue(3)：217-220,4.
MiR-137在缺血性卒中后抑郁患者外周血中的表达及其临床意义
Expression and its clinical significance of miR-137 in peripheral blood of patients with depression after ischemic stroke
鲁豫 1田小军 1史莉瑾 1苏洲 1郭双喜 1王玉梅1
作者信息
- 1. 453100 新乡医学院第一附属医院神经内科
- 折叠
摘要
Abstract
Objective To explore the changes of miR-137 of patients with depression after ischemic stroke and its clinical significance.Methods All the patients were separately divided into four groups according to the following rating scales: 2014 diagnostic criteria for acute cerebral infarction, Hamilton depression scale(HAMD-24), Diagnostic and statistical manual of mental disorders, the fifth edition (DSM-5)were applied to categorizing.According to the above grouping standards,all the patients were grouped as normal control group (n=20),the depression group (n=20), post-stroke depression group (n=37),no depression after stroke group (n=37).The expression level of microRNA(miR)-137 in each group was detected by quantitative real-time PCR(qRT-PCR),and the results were compared.Results The difference of gender,age,chronic dieases,the site of infarction,NIHSS score had no statistical significance in the four group (all P>0.05).Compared with no depression after stroke group, the number of patients with left cerebral infarction was significantly increased in post-stroke depression group(P<0.05).Compared with the normal control group,miR-137 in no depression after stroke group and in post-stroke depression group significantly decreased(allP<0.05);compared with no depression after stroke group, miR-137 in post-stroke depression group significantly decreased(P<0.05);the level of miR-137 between post-stroke depression group and depression group showed no statistical significance (P>0.05).Conclusions Ischemic stroke can induce the low expression of miR-137 which participates in the formation of post-stroke depression.miR-137 may act as a predictive,diagnostic,therapeutic index of poststroke depression.关键词
脑卒中/卒中后抑郁/miR-137Key words
stroke/post-stroke depression/miR-137分类
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鲁豫,田小军,史莉瑾,苏洲,郭双喜,王玉梅..MiR-137在缺血性卒中后抑郁患者外周血中的表达及其临床意义[J].临床神经病学杂志,2017,30(3):217-220,4.
