临床误诊误治2017，Vol.30Issue(7)：85-88,4.DOI:10.3969/j.issn.1002-3429.2017.07.026
血清胃泌素-17在结肠息肉患者中的表达及临床意义
Expression and Significance of Serum Gastrin-17 in Patients with Colonic Polyps
摘要
Abstract
Objective To investigate correlation between serum gastrin-17 (G-17) and colonic polyps pathogenesy, and to evaluate its diagnostic value in screening colonic polyp.Methods A total of 194 cases of colonic polyps during December 2015 and October 2016 were selected as colonic polyps group, and other 100 cases without colonic abnormalities at the same period were chosen as control group.Serum G-17 levels and G-17 positive rates were detected by enzyme-linked immunosorbent assay (ELISA), and receiver operating curve (ROC) was drawn further to find the best cut-off value in diagnosis of colonic polyps.Relationships between serum G-17 level and pathological types, lesion locations and number of colonic polyps were observed by subgroup analysis of colonic polyps.Results In colonic polyps group, serum G-17 level was significantly higher (t=7.513, P=0.000), and the positive rate of G-17 was significantly higher than those in control group (χ2=91.424, P=0.000).ROC showed that the best cut-off value of G-17 in diagnosis of colonic polyps was 15.16 pmol/L, and diagnostic sensitivity and specificity were 61.7% and 81.2% respectively.The subgroup analysis of colonic polyps group showed that the G-17 level was significantly higher in the subgroup of adenomatous polyposis with higher malignant degree than those in inflammatory, proliferative and mixed polyps subgroups, and the differences were statistically significant (vs inflammation subgroup: t=3.265, P=0.002;vs hyperplasia subgroup: t=2.210, P=0.039;vs mixed subgroup: t=2.122, P=0.034);but G-17 levels showed no relationships with the location and number of polyps.Conclusion Serum G-17 may be associated with pathogenesy and pathological types of colonic polyps, and it is expected to be a method for clinical prediction and screening of colonic polyps.关键词
结肠息肉/胃泌素-17/预测/筛查Key words
Colon polyps/Gastrin-17/Forecasting/Screening分类
医药卫生引用本文复制引用
徐茜,冯如,闾永健,岳苏阳,费素娟..血清胃泌素-17在结肠息肉患者中的表达及临床意义[J].临床误诊误治,2017,30(7):85-88,4.基金项目
江苏省高校自然科学研究项目(14KJB320021) （14KJB320021）
