老年医学与保健2017，Vol.23Issue(3)：181-182,200,3.
阿托伐他汀对急性心肌梗死患者血清C-反应蛋白和白细胞介素-1的影响及临床意义
Effects of Atorvastatin on Interleukin-1 and C-reactive Protein Levels of Patients with Acute Myocardial Infarction
摘要
Abstract
Objective To observe the effect of different dose of atorvastatin on interleukin-1 (IL-1) and C-reactive protein (CRP) levels of patients with acute myocardial infarction (AMI) so as to provide reference for the determination of the dose-effect relationship.Methods 80 patients with AMI were randomly divided into 2 groups:observation group and control group,40 in each;oral administration of atorvastatin 20 mg per day was made to patients in control group while that of atorvastatin 40 mg per day was made to patients in observation gorup;the course lasted for 4 weeks for both groups;40 norm were selected to be blank control group;detections of CRP and IL-1 levels before and after treatment were performed in each group and the results were compared and analyzed.Results Before treatment,the CRP and IL-1 levels of the patients in observation group and control group were much higher than those in blank control group (P＜0.01);after treatment,the levels of CRP and IL-1 of the patients in both group were obviously lower than those before treatment (P＜0.01) and the levels in observation group were much lower than those in control group (P＜0.01).Conclusions The administration of atorvastatin to patients with early AMI can effectively control the inflammation and the dose-effect relationship may help the stability of lipid plaques and the improvement of prognosis.关键词
阿托伐他汀/急性心肌梗死/白细胞介素-1/C-反应蛋白/量效反应Key words
atorvastatin/acute myocardial infarction (AMI)/interleukin-1 (IL-1)/C-reactive protein (CRP)/dose-effect relationship引用本文复制引用
蒋庆渊,陆铭,李锦玉,李志强,刘春兰,刘莹莹..阿托伐他汀对急性心肌梗死患者血清C-反应蛋白和白细胞介素-1的影响及临床意义[J].老年医学与保健,2017,23(3):181-182,200,3.基金项目
上海市浦东新区卫生和计划生育委员会基金项目(PW2012A-31) （PW2012A-31）
