热带作物学报2017，Vol.38Issue(6)：1134-1137,4.DOI:10.3969/j.issn.1000-2561.2017.06.024
五指毛桃抗炎活性成分的分离及鉴定
Isolation and Identification of Chemical Constituents with Anti-inflammatory Activity from the Roots of Ficus hirta Vahl.
摘要
Abstract
To investigate the anti-inflammatory activity of the roots of Ficus hirta Vahl.5-lipoxygenase (5-LOX) inhibitory activity was selected as the evaluation index.Six compounds were separated from this material by 5-zlipoxygenase inhibitory activity-guided isolation.Their structures were identified as lupeol palmitate (1),β-amyrin acetate (2),psoralen (3),apigenin (4),azelaic acid (5),daucosterol (6) on the basis of NMR spectroscopic analyses.Compound 5 and 1 exhibited strong in vitro inhibitory activity on 5-LOX with IC50 values 13.74 μg/mL and 13.96 μg/mL,respectively.Compound 1 was reported for the first time from F.hirta roots.The results may provide theoretical supports for the anti-inflammatory effect and clinical application of F.hirta roots.关键词
五指毛桃/抗炎活性/5-LOX抑制活性/化学成分/结构鉴定Key words
Ficus hirta Vahl.roots/anti-inflammatory activity/5-LOX inhibitory activity/chemical constituents/structure identification分类
医药卫生引用本文复制引用
吕镇城,陈康,彭永宏..五指毛桃抗炎活性成分的分离及鉴定[J].热带作物学报,2017,38(6):1134-1137,4.基金项目
惠州学院博士启动项目(No.C513.0204) （No.C513.0204）
惠州市科技计划项目(No.2014B040008001). （No.2014B040008001）
