四川医学2017，Vol.38Issue(7)：805-808,4.DOI:10.16252/j.cnki.issn1004-0501-2017.07.026
右美托咪定和阿芬太尼对开颅动脉瘤夹闭术后恢复期的影响
Effect of Dexmedetomidine and Alfentanil on Post-operation Recovery Period after Aneurysm Clipping by Craniotomy
伍志超 1王涵 1包晓航2
作者信息
- 1. 南充市中心医院麻醉科,四川 南充 637000
- 2. 第三军医大学新桥医院麻醉科,重庆 400030
- 折叠
摘要
Abstract
Objective To compare effect of Dexmedetomidine and Alfentanil on breath,blood circulation and analepsia in post-operation recovery period after aneurysm clipping by craniotomy with general anesthesia.Methods This study was designed as a randomized controlled trial.90 cases of unruptured intracranial aneurysm patients,graded ASA I-II,whose body mass index(BMI)ranging from 20 to 25kg/m2,were included to undergo aneurysm clipping by craniotomy under intravenous-inhalation combined general anesthesia.Patients were randomly divided into three groups:Dexmedetomidine group(n=30),Alfentanil group(n=30)and control group(n=30).Before the end of surgery,0.5μg/kg of Dexmedetomidine was administrated by computerized infusion pump for 5min in Dexmedetomidine group,10μg/kg of Alfentanil was given in Alfentanil group and in the control group,equal volume of normal saline was given.Patients were transferred to Post Anesthesia Care Unit(PACU)after surgery.Haemodynamics indexes at different time points of post-operation recovery period(time of reaching PACU defined as T0,time of extubation defined as T1 and 10 minutes after extubation defined as T2),respiratory rates and sedation scores at T2,as well as extubation time were observed and recorded.Results Differences of post-operation haemodynamics indexes,respiratory rates and sedation scores after extubation among three groups were statistically significant(P<0.05),but differences of extubation time were not statistically significant(P>0.05).Conclusion Dexmedetomidine and Alfentanil were able to make the haemodynamics more stable and post-operation sedation better in recovery period for patient just undergoing aneurysm clipping by craniotomy,without prolonging extubation time.Furthermore,Dexmedetomidine has better respiratory protective effect than Alfentanil.关键词
恢复期/动脉瘤夹闭/右美托咪定/阿芬太尼Key words
recovery period/aneurysm clipping/dexmedetomidine/alfentanil分类
医药卫生引用本文复制引用
伍志超,王涵,包晓航..右美托咪定和阿芬太尼对开颅动脉瘤夹闭术后恢复期的影响[J].四川医学,2017,38(7):805-808,4.
