肿瘤预防与治疗2017，Vol.30Issue(3)：174-181,8.DOI:10.3969/j.issn.1674-0904.2017.03.005
新辅助化疗联合同步放化疗对局部晚期鼻咽癌预后影响的Meta分析
Neoadjuvant Chemotherapy followed by Concurrent Chemoradiotherapy for the Prognosis of Locally Advanced Nasopharyngeal Carcinoma:A Meta-analysis
杨健筌 1郭文 2文世民 1李德智 1郭翠华 1张欣平 1别俊 1胡欣 1李光明1
作者信息
- 1. 637000四川 南充,南充市中心医院肿瘤中心
- 2. 637000四川 南充,四川省南充卫生学校
- 折叠
摘要
Abstract
Objective: To evaluate the survival of patients with locally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy compared with concurrent chemoradiotherapy alone.Methods: Seven databases were searched,including the Cochrane Library(Issue 2,2016),Pubmed,Embase,CBM,CNKI,VIP and Wanfang Database.The methodological quality assessment of eligible researches was conducted according to the Jadad scale and The Newcastal-Ottawa Scale.The Meta-analysis was performed by the Revman 5.3 software.Results: Eleven researches containing 1 521 patients were finally included.The 5-year distant metastasis-free survival of patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy was significantly higher than that of those treated with concurrent chemoradiotherapy alone.There were no significant difference in 3-year overall survival,3-year distant metastasis-free survival,3-year progression-free survival,3-year recurrence free survival,5-year overall survival,5-year progression-free survival and 5-year recurrence free survival (P>0.05) respectively between these two regimens.Conclusion: Current evidence shows that compared with concurrent chemoradiotherapy alone,neoadjuvant chemotherapy followed by concurrent chemoradiotherapy could improve distant metastasis-free survival in locally advanced nasopharyngeal carcinoma,while no difference was found of the total survival between these two regimens.关键词
鼻咽癌/新辅助化疗/同步放化疗/Meta分析Key words
Nasopharyngeal Carcinoma/Neoadjuvant Chemotherapy/Concurrent Chemoradiotherapy/Meta Analysis分类
医药卫生引用本文复制引用
杨健筌,郭文,文世民,李德智,郭翠华,张欣平,别俊,胡欣,李光明..新辅助化疗联合同步放化疗对局部晚期鼻咽癌预后影响的Meta分析[J].肿瘤预防与治疗,2017,30(3):174-181,8.
