肿瘤预防与治疗2017，Vol.30Issue(3)：186-190,5.DOI:10.3969/j.issn.1674-0904.2017.03.007
单中心25例隐匿性乳腺癌的临床病理特征及预后分析
Clinicopathological Features and Prognosis of 25 Occult Breast Cancer Cases:A Single Center Study
蒋莉 1田廷伦 1钟晓蓉 1罗婷 1鄢希1
作者信息
- 1. 610041成都,四川大学华西医院 肿瘤科一病房
- 折叠
摘要
Abstract
Objective: Retrospective analysis of occult breast cancer(OBC) patients with a preliminary study of clinical and pathological characteristics as well as prognostic factors.Methods: Twenty-five cases of OBC were collected in the Oncology Center of West China Hospital,Sichuan University,from October 2001 to June 2016.Kaplan-Meier method was used to calculate the survival rate and create survival curve.Log-rank test and COX regression model were separately utilized for univariate and multivariate analysis of overall survival (OS).Results: The 5-year OS was 57.8%.The positive rate of estrogen receptor (ER) was 48%,the progesterone receptor (PR) 52% and the human epithelial growth factor receptor 2 (HER2) 32%.Univariate analysis showed that PR status,radiotherapy,endocrine therapy and distant metastasis were potential prognostic factors.Multivariate analysis showed that the occurrence of distant metastasis was the only statistically significant factor which reduced the overall survival rate(HR=0.131;95%CI,0.020~0.835;P=0.031).Conclusion: The incidence of occult breast cancer is low and the diagnosis is difficult.Distant metastasis is an important prognostic factor.Combination therapy including surgery,chemotherapy,radiotherapy,endocrine therapy and targeted therapy is an important strategy to improve the overall survival of patients with occult breast cancer.关键词
隐匿性乳腺癌/临床病理/预后Key words
Occult Breast Cancer/Clinicalpathology/Prognosis分类
医药卫生引用本文复制引用
蒋莉,田廷伦,钟晓蓉,罗婷,鄢希..单中心25例隐匿性乳腺癌的临床病理特征及预后分析[J].肿瘤预防与治疗,2017,30(3):186-190,5.
