同济大学学报（医学版）2017，Vol.38Issue(3)：56-59,65,5.DOI:10.16118/j.1008-0392.2017.03.011
西洛他唑联合氯吡格雷对冠状动脉药物涂层支架术后支架内再狭窄的影响
Effect of cilostazol combined with clopidogrel on in-stent restenosis after coronary drug-eluting stenting
李继敏 1叶梓 1邹誉 1李莹1
作者信息
- 1. 同济大学附属东方医院心内科,上海 200120
- 折叠
摘要
Abstract
Objective To investigate the occurrence of in-stent restenosis (ISR) of patients using cilostazol combined with clopidogrel as dual antiplatelet therapy (DAPT) following drug-eluting stenting.Methods In this retrospective study, we enrolled 231 patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent and all patients underwent coronary angiography (CAG) at one year after PCI.Patients were divided into two groups according to differential DAPT.There were 17 patients using cilostazol and clopidogrel as DAPT after PCI (cilostazol group) and 214 patients using conventional aspirin combined with clopidogrel as DAPT (aspirin group).The occurrences of ISR and target vessel revascularization (TVR) were compared at one year after PCI between two groups.Results There were no significant differences in baseline characteristics between two groups, except that more males and more patients with history of gastrointestinal bleeding in cilostazol group than those in aspirin group (88.2% vs 76.6%, P <0.001, 35.3% vs 0.9%, P <0.001;respectively).At one year after PCI, the ISR rate of cilostazol group was no significantly different with that in aspirin group (29.4% vs 12.1%, P =0.06).Rates of TVR (5.9% vs 6.1%, P =0.974) and PCI for other lesions (17.6% vs 15.4%, P =0.734) were similar between the two groups.Conclusion Efficacy of cilostazol based DAPT in reducing ISR was similar with conventional DAPT in patients after PCI.Cilostazol as an alternative to aspirin in patients with high risk of gastrointestinal bleeding or aspirin intolerance may be appropriate.关键词
冠心病/支架/阿司匹林/西洛他唑/氯吡格雷Key words
coronary heart disease/stent/aspirin/cilostazol/clopidogrel分类
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李继敏,叶梓,邹誉,李莹..西洛他唑联合氯吡格雷对冠状动脉药物涂层支架术后支架内再狭窄的影响[J].同济大学学报（医学版）,2017,38(3):56-59,65,5.
