同济大学学报（医学版）2017，Vol.38Issue(3)：66-69,4.DOI:10.16118/j.1008-0392.2017.03.013
角膜塑形镜对青少年中低度近视患者角膜厚度和角膜内皮的影响
Effects of orthokeratology lens on corneal thickness and endothelia in adolescents with moderate-low myopia
摘要
Abstract
Objective To investigate the effects of orthokeratology (OK) lens on the central corneal thickness (CCT) and endothelial cells in moderate-low myopic adolescent patient.Methods Fifty eight moderate-low myopic adolescent patients (109 eyes) treated with OK lenses were enrolled from March 2010 to August 2013, including 24 males and 34 females.They were fitted with overnight OK lens for 7h.The average baseline spherical equivalent refraction error was (-2.58±1.12) diopters (D) (-0.25 D to-5.25 D) before the treatment.The thickness measurements in the central cornea were obtained by A scan pachymeter;the cornea endothelial cell density, average cell area, coefficient of variation and hexagonal cell ratio were analyzed by endothelial microscopy before and 1d, 1, 2 weeks and 1, 3, 6 months after wearing OK lens.Corneal conjunctival complications rate was evaluated by cornea fluorescent.The above parameters were measured every six months after treatment.Results The mean CCT values before and 6, 12, 24 months after OK lens wearing were (560.97±32.57), (559.68±31.18),(557±32.27) and (557.24±30)μm, respectively ( F=0.393, P=0.758 ).There were no significant differences in cornea endothelial cell density, average cell area, coefficient of variation and hexagonal cell ratio at the different time points of OK wearing ( P >0.05).Corneal conjunctival complications rate was 20.18%, and no severe complications were observed.Conclusion In generally, long-term wearing of rigid gas permeable contact lenses is safety for mild-moderate myopic adolescent patients.关键词
角膜塑形镜/近视/角膜厚度/角膜内皮/安全性Key words
orthokeratology lens/myopia/corneal thickness/corneal endothelial/safety分类
医药卫生引用本文复制引用
杜亚茹,梁秀玮,危清泉,金惠子,张瑞玲,于靖..角膜塑形镜对青少年中低度近视患者角膜厚度和角膜内皮的影响[J].同济大学学报（医学版）,2017,38(3):66-69,4.基金项目
国家自然科学基金(81470648) （81470648）
