This work was supported by Hong Kong Baptist University Faculty Research Grant Category Ⅱ. Grant No.: HKBU/FRG2/13-14/025 and Shenzhen Science and Technology Innovation Committee JCYJ20140419130444178. Neither the funding agency nor any outside organization had a role in study design or manuscript preparation. This is not a com-mercial sponsored study. Zhao-Xiang Bian is the correspond-ing author and designed the study. Linda Li-Dan Zhong and Kun Wai drafied the protocol and enrolled the participants. Dong-Dong Hu and Ling Zhao collected the biological sam-ples. Dong-Dong Hu and Huai-Xue Mu pretreated the plasma and urine samples. Dong-Dong Hu conducted the LC-MS/MS analysis, data processing and drafied the manuscript. Linda Li-Dan Zhong, Kun Wai, Ling Zhao, Cheng-Yuan Lin, Tao Huang and Zhao-Xiang Bian revised the manuscript and gave critical advises. All authors read and approved the final manuscript. We thank Hong Kong Baptist University Faculty Research Grant Category Ⅱ. Grant No.: HKBU/FRG2/13-14/025 for supporting this project. Special thanks to all the patients who participated in this study. （）