护理研究2017，Vol.31Issue(22)：2712-2717,6.DOI:10.3969/j.issn.1009-6493.2017.22.008
芳香疗法在高危神经母细胞瘤患儿化疗相关恶心呕吐中的应用研究
Application study on aromatherapy in chemotherapy-induced nausea and vomiting in children with high-risk neuroblastoma
摘要
Abstract
Objective: To explore the effect of aromatherapy on chemotherapy-induced nausea and vomiting (CINV) in children with high-risk neuroblastoma (NB).Methods: From November 2015 to July 2016,patients with high-risk NB were treated with high-dose drugs chemotherapy in Blood Tumor Center of Beijing Children's Hospital They were selected as the research objects.The chemotherapy regimen included CAV regimen (cyclophosphamide + adriamycin+vincristine)and CVP regimen (cisplatin + etoposide).The self-contrast was used,and according to the random number table,a ill child using the same chemotherapy program was taken as the experimental group and control group respectively before and after.The patients in experimental group were given aromatherapy on the basis of antiemetic drugs,while the patients in control group were given only antiemetic drugs and the intervention last for 5 days.The Chinese version of Index of Nausea Vomiting Retching scale was used to assess the occurrence frequency,experience time and the severity of three symptoms including nausea,vomiting,and vomiturition of the two groups of children.The vomiting self-assessment results and acceptable degree of aromatherapy were assessed after intervention.Results: A total of 39 cases were included in this study.A total of 76 cases/times of chemotherapy.There were 72 effective cases/times,36 cases/times of the experimental group,36 cases/times of the control group,46 cases/times of the CAV program,and 26 cases/times of the CVP program.The children's experience time,occurrence frequency,and severity of CINV were gradually increased,and reached the peak on the third day to the fourth day after chemotherapy,while the symptoms in experimental group was less than those in control group (except the intraday).The experience time,occurrence frequency,and severity of nausea,vomiting and vomiturition symptoms in experimental group were less than those in control group,in which there was the statistical significant difference in severity (P<0.05).During the period of CAV regimen,there was no significant difference in CINV between the two groups (P>0.05).During the period of CVP regimen,the experience time and occurrence frequency of nausea in experimental group were less than those in control group (P<0.05).The severity of vomiting on the third day to the fifth day was lower than that in control group(P<0.05).The experience time and severity of vomiturition on the third day to the fifth day were lower than that in control group (P<0.05).In parental self-assessment results, 5 cases/times (13.9%) with aromatherapy after nausea and vomiting improved significantly,25 cases/times (69.4%) improved,4 cases/times (11.1%) did not change,2 cases/times (5.6%) felt worse.In the acceptance degree of parents,19 cases/times(52.8%)believed that aromatherapy was very simple,17 cases/times (47.2%) believed it was simple,9 cases /times (25.0%)were very satisfied with the aromatherapy,22 cases/times (61.1%) were satisfied,4 cases/times (11.1%) thought it was ok,1 case//time was not satisfied,8 cases/times(22.2%)were very likely to continue to use,20 cases/times (55.6%) hoped to use continually,7 cases/times(19.4%) thought it was ok,1 case/time(2.8%)did not want to continue to use.There was no allergic reaction in the experimental group.Conclusions: CINV in children with high-risk NB has the highest and most serious incidence,especially delayed nausea and vomiting on the intraday to the first day after the end of chemotherapy.Aromatherapy could relieve the severity of nausea and vomiting in high-risk NB patients,especially reduce the experience time and severity of vomiturition and severity of vomiting during the period of CVP regimen on the third day to the fifth day.It was acceptable for parents and older ill children.关键词
芳香疗法/神经母细胞瘤/化疗/恶心/呕吐/儿童Key words
aromatherapy/neuroblastoma/chemotherapy/nausea/vomiting/children分类
医药卫生引用本文复制引用
王旭梅,王莉,王希思,丁亚光,赵文,彭晓霞,吴心怡,马晓莉..芳香疗法在高危神经母细胞瘤患儿化疗相关恶心呕吐中的应用研究[J].护理研究,2017,31(22):2712-2717,6.基金项目
首都临床特色应用研究项目,编号:Z151100004015159. （）
