现代检验医学杂志2017，Vol.32Issue(3)：14-17,4.DOI:10.3969/j.issn.1671-7414.2017.03.004
老年住院患者感染鲍曼不动杆菌克隆相关性及耐药表型分析研究
Clonal Relatedness and Antimicrobial Susceptibility Profiling of Acinetobacter Baumannii Isolates from Senile Patients
摘要
Abstract
Objective To investigate the clonal relatedness of A.baumannii isolates from senile patients by conducting cross-sectional and longitudinal studies on antimicrobial susceptibility profiling and genomic diversity.Methods Cross-sectional study was done among the 170 non-repetitive A.baumannii isolates which were collected from senile patients during two years.Longitudinal study was conducted among 77 A.baumannii collected from 8 senile patients within longtime hospitalization.Results 75.3 ％ of the 170 isolates were non-susceptible to carbapenems,and the phenotype were XDR or MDR which spread evenly all over the senile wards.The isolates belonged to 36 pulsotypes determined by PFGE.Groups Ⅰ (contain119 isolates) were major epidemic strains,which were CRAB with XDR phenotype.In longitudinal study,comparison of pulsotypes was performed for each patient and all isolates were clustered into group Ⅰ except one isolate.All the 77 isolates were XDR.Conclusion Extensive drug-resistance of A.baumannii was a serious problem in the gerontal wards.Clone dissemina tion was the most important style of XDR strains spread.Horizontal infection control measures to interrupt person-to-person transmission should be reinforced to reduce the further spread of XDR A.baumannii.关键词
鲍曼不动杆菌/医院获得性感染/泛耐药/分子流行病学Key words
Acinetobacter baumannii/hospital-acquired infections/extensive drug-resistance/molecular epidemiology分类
医药卫生引用本文复制引用
周玉,曲芬,龚美亮,徐雅萍,陈素明,丛玉隆,邓新立..老年住院患者感染鲍曼不动杆菌克隆相关性及耐药表型分析研究[J].现代检验医学杂志,2017,32(3):14-17,4.基金项目
全军医学科技“十二五”科研项目重点课题(BWS11-C073). （BWS11-C073）
