陕西医学杂志2017，Vol.46Issue(6)：796-798,3.DOI:10.3969/j.issn.1000-7377.2017.06.046
低分子肝素联合氟桂利嗪对频发性TIA患者脑梗死的预防效应
The effects of low molecular weight heparin combined with flunarizine on the prevention of cerebral infarction to patients with the frequency transient ischemic attack
张立红 1李迪 1康永琨 2王明珠 3许建平 4王苏平1
作者信息
- 1. 大连医科大学附属大连市中心医院神经内一科 大连116033
- 2. 大连医科大学附属第二医院影像科 大连116023
- 3. 辽宁省大连市第四医院重症医学科 大连116000
- 4. 苏州大学附属第一医院 苏州215006
- 折叠
摘要
Abstract
Objective:To evaluate the clinical effects of low molecular weight heparin (LMWH) combined with flunarizine on the prevention of cerebral infarction (CI) to patients with the frequency transient ischemic attack (TIA).Methods:A total of 132 patients with the frequency TIA were chosen and divided into two groups,control group (65 cases,application with LMWH) and research group (67 cases,application with LMWH combined with flunarizine),based on distinct chemotherapies.All patients were received the basic therapy of anti-platelet and lipid regulation.The course of two groups' patients was two weeks.The indexes of hemorheology and coagulation system were detected and compared between two groups.Follow-up three months,the recurrence rate of TIA and the occurrence of CI were recorded and compared between two groups.The occurrences of all kinds of adverse reaction were compared between two groups.Results:Compared to control group,the rates of overall response (OR) and partial response (PR) were higher (P＜0.05).The post-therapy indexes of whole blood viscosity (low cut),whole blood viscosity (high shear),plasma viscosity,PT,INR,fibrinogen in two groups were lower significantly than the pre-therapy (P＜0.05),but the above post-therapy indexes in research group were lower than those in control group (P＜0.05).The recurrence rate of TIA and the occurrence of CI in research group were lower than those in control group (P＜0.05).The occurrences of all kinds of adverse reaction were no different between two groups.Conclusion:The combination of LMWH and flunarizine can decrease the frequency of TIA and the occurrence of CI.关键词
脑缺血发作,短暂性/药物疗法/肝素,低分子量/治疗应用/氟桂利嗪/治疗应用/脑梗塞/预防与控制Key words
Schemic attack, transient/drug therapy/Heparin, low-molecular-weight/therapeutic use/Flunarizine/therapeutic use/Brain infarction/prevention & control分类
医药卫生引用本文复制引用
张立红,李迪,康永琨,王明珠,许建平,王苏平..低分子肝素联合氟桂利嗪对频发性TIA患者脑梗死的预防效应[J].陕西医学杂志,2017,46(6):796-798,3.
