实用医学杂志2017，Vol.33Issue(11)：1846-1849,4.DOI:10.3969/j.issn.1006-5725.2017.11.033
七氟醚后处理对糖尿病患者体外循环手术的心肌保护作用
Cardioprotective effects of sevoflurane postconditioning on surgery patients undergoing cardiopulmonary bypass with diabetes mellitus
摘要
Abstract
Objective To investigate the Cardioprotective effects of sevoflurane postconditioning on surgery patients undergoing cardiopulmonary bypass with diabetes mellitus ,in order to provide theoretic basic for clinical practic. Methods 180 patients of undergoing cardiopulmonary bypass sugery were divided into 3 groups:A group:64 patients undergoing heart valve replacement with Type II diabetes. B group:64 patients Pa-tients undergoing heart valve replacement without diabetes ,the group A and B were treated by sevoflurane post-conditionging for 10 minutes before the end of cardiopulmonary bypass. C group:60 patients undergoing heart valve replacement without diabetes,no sevoflurane postconditionging;Three groups of patients detect perioperative tro-ponin T and Creatine Kinase Isoenzyme-MB ,observed and following up the occurrence of postoperative com-plications. Results CK-MB and cTnT were compared at 8 and 24 hours after operation:two biochemical indi-cators of group A and C at different time points after operation were significantly higher than those in group B (P < 0.05),With significant statistical difference , The number of patients with heart failure and malignant arrhythmia in group A and C was higher than group B(P < 0.05),Differences in 30 day mortality and other clinical data between the three groups were not statistically significant. Conclusion Sevoflurane postconditionging has significant myocardial protection effect for patients undergoing valve replacement surgery without diabetes , however ,the myocardial protective effect of patients who undergoing valve replacement surgery with diabetes was weakened.关键词
七氟醚/瓣膜病/并发症/糖尿病Key words
Sevoflurane/Valvular heart disease/Complications/Diabetes mellitus引用本文复制引用
罗丹,徐潍昉,马海平..七氟醚后处理对糖尿病患者体外循环手术的心肌保护作用[J].实用医学杂志,2017,33(11):1846-1849,4.基金项目
基金编号:新疆维吾尔自治区自然科学基金(编号:2015211C058) （编号:2015211C058）
