实用医学杂志2017，Vol.33Issue(12)：1936-1938,3.DOI:10.3969/j.issn.1006-5725.2017.12.010
银杏叶提取物对慢性阻塞性肺疾病大鼠CRP、TNF-α的影响
Effects of ginkgo biloba extract on CRP and TNF-α in rats with chronic obstructive pulmonary disease
摘要
Abstract
Objective To study the effects of ginkgo biloba extract(GBE)on c-reactive protein(CRP) and tumor necrosis factor-α(TNF-α)in serum and alveolar lavage fluid(BALF)from rats with chronic obstructive pulmonary disease(COPD). Methods 90 rats were randomly divided into groups A,B,C,D,E and F. There were 15 rats in each group. The rat model of COPD were established in groups B,C,D,E and F. Groups C and D were given intraperitoneal injections with GBE from day l to day l4 and day 29 to day 42. Groups E and F weregiven intraperitoneal injections with erythromycin from day l to day l4 and day 29 to day 42. After the end of experi-ment ,the contents of CRP and TNF-α in serum and BALF were detected in all groups. Results The contents of CRP and TNF-α in the serum and the BALF were markedly lower in groups C,D,E and F than in group B (P<0.05);and the contents of CRP in the serum and the BALF and TNF-αin the BALF were lower in groups C, E and F than in group D(P<0.05). Conclusions GBE can inhibit the airway and systemic inflammatory response in COPD rats. Early intervention is more effective.关键词
慢性阻塞性肺疾病/银杏叶提取物/C反应蛋白/肿瘤坏死因子-αKey words
Chronic obstructive pulmonary disease/Ginkgo biloba extract/CRP/TNF-α引用本文复制引用
梁炜,杨红梅,梁爱武,杨益宝,冯玉青,张鹏飞,李瑞祥,谭玉萍..银杏叶提取物对慢性阻塞性肺疾病大鼠CRP、TNF-α的影响[J].实用医学杂志,2017,33(12):1936-1938,3.基金项目
国家自然科学基金项目(编号:81260005) （编号:81260005）
