实用医学杂志2017，Vol.33Issue(13)：2136-2139,4.DOI:10.3969/j.issn.1006-5725.2017.13.017
高龄二孩孕妇的产前诊断结果
The results of prenatal diagnosis in women with advanced maternal age under the universal two-child poli-cy
摘要
Abstract
Objective To analyze the fetus chromosome abnormalities in women with advanced maternal age under the universal two-child policy. Methods A total of 10607 women underwent prenatal diagnosis proce-dures from the year of 2015 to 2016,among which 3569 cases were with advanced maternal age. Cytogenetic karyotyping was conducted with chromosomal microarray analysis(CMA)in 854 cases. The ration of chromosome abnormalities in the two population groups(aged from 35~39 and over 40)were counted. The type of abnormali-ties were also analyzed. Results The ration of women with advanced maternal age in 10607 cases underwent pre-natal diagnosis between 2015 and 2016 was 33.6%. The respective rations were 27.2%and 37.9%. The detection rates of chromosome abnormalities were 7.9% and 10.8%,with significantly difference. The significant differences were also found in the detection rate of chromosome aneuploidies ,but no differences in other chromosome abnor- malities. CMA was benefit to detect the micro chromosome abnormalities. Conclusions In 2016,the number of prenatal diagnosis procedures increased under the two-child policy. The detection rate of chromosome abnormalities also significantly increased. The incidence of chromosome abnormalities was higher with the growing age of preg-nant women. Genetic counseling must be presented and prenatal diagnosis should be promoted in women with ad-vanced age.关键词
高龄妊娠/产前诊断/胎儿染色体/染色体微阵列分析Key words
keywords advanced pregnancy/prenatal diagnosis/fetal chromosome/chromosome mi-croarray analysis引用本文复制引用
麦明琴,熊盈,陈汉彪,卢建,赵馨,张春婷..高龄二孩孕妇的产前诊断结果[J].实用医学杂志,2017,33(13):2136-2139,4.基金项目
广东省医学科研基金资助项目(编号:A2013079) （编号:A2013079）
