实用医学杂志2017，Vol.33Issue(14)：2336-2340,5.DOI:10.3969/j.issn.1006-5725.2017.14.022
吸烟和血小板分布宽度对冠心病患者氯吡格雷抵抗的影响
Impact of smoking and platelet distribution width on clopidogrel resistance in patients with coronary ar-tery disease LI
刘艳红 1焦占全 2李彤 1刘迎午 1彭文近 1宁萌1
作者信息
- 1. 300170 天津市第三中心医院心脏中心,天津市人工细胞重点实验室,卫生部人工细胞工程技术研究中心
- 2. 300211 天津医科大学第二医院心脏科
- 折叠
摘要
Abstract
Objective To explore the influence of smoking on clopidogrel resistance in patients with coro-nary artery disease. Methods A total of 216 patients with coronary artery disease who accept selective percutane-ous coronary intervention in our hospital from May 2015 to December 2015 were selected as study subjects;their average age was 63 years old ,146 were male and 70 were female. All the patients were divided into clopidogrel resistance group (CR group) and normal clopidogrel response group (NCR group) according to the results of platelet aggregation test. History of smoking ,alcohol drinking and diabetes mellitus ,baseline medication uses , level of platelet counts,platelet distribution width,mean platelet volume,HbA1c,and results of echocardiogram and coronary angiography were compared between the two groups. Results The rate of smoking was significantly higher in CR group than in NCR group (P < 0.05). The changed value of PDW before and after treatment with clopidogrel was smaller in CR group than in NCR group ,the difference was statistically significant (P < 0.05). Conclusions Smoking may be a protective factor for clopidogrel resistance. The changed value of PDW before and after treatment with clopidogrel can reflect the level of clopidogrel resistance.关键词
冠心病/氯吡格雷抵抗/吸烟/血小板分布宽度Key words
coronary artery disease/clopidogrel resistance/smoking/platelet distribution width引用本文复制引用
刘艳红,焦占全,李彤,刘迎午,彭文近,宁萌..吸烟和血小板分布宽度对冠心病患者氯吡格雷抵抗的影响[J].实用医学杂志,2017,33(14):2336-2340,5.
