天津中医药2017，Vol.34Issue(7)：443-445,3.DOI:10.11656/j.issn.1672-1519.2017.07.04
通痹胶囊治疗类风湿关节炎(寒湿痹阻型)临床疗效及安全性观察
Observation of clinical curative effect and security of Tongbi capsule in treating rheumatoid arthritis (syndrome of cold﹣ dampness blocking the channals and collaterals)
摘要
Abstract
[Objective] To observe the clinical effectiveness and safety of the Tongbi capsule in treating rheumatoid arthritis(syndrome of cold-dampness blocking the channals and collaterals). [Methods] The 100 cases of rheumatoid arthritis (syndrome of cold-dampness blocking the channals and collaterals) of patients were randomly divided into two groups, 50 cases in each group. The control group were treated with LEF+MTX, while the treatment group were based on the Tongbi capsule treatment. Observed two groups of curative effect of TCM syndrome before and after therapy, Chinese medicine clinical symptoms integral, ACR20, ACR50, IL-1, IL-6, the changes of TNF-a, at the same time observe the blood routine, liver and kidney function safety indexes such as changes in order to understand the clinical application of security. [Results] Treatment group can significantly reduce the clinical symptoms of traditional Chinese medicine integral (P<0.05), especially in the numbness, afraid of cold symptoms such as improving. Performance was particularly significant difference. One year after treatment in treatment group ACR20, ACR50 respectively 88%, 74%, significantly higher than the control group were 66%, 60% (P<0.05). Tongbi capsule can better reduce the IL-1, IL-6, the content of TNF-a, can significantly reduce and alleviate the clinical symptoms of patients. In the two groups in safety indexes such as liver and kidney function, no significant differences in the comparison of the safety tips curative effect of two groups. [Conclusion] Based on joint slow-acting drug treatment with Tongbi capsule treat syndrome of cold-dampness blocking the channals and collaterals arthritis with syndrome of cold-dampness blocking the channals and collaterals to improve the chills, numbness syndrome of traditional Chinese medicine has good effect, has good clinical efficacy and safety.关键词
通痹胶囊/类风湿关节炎/寒湿痹阻型/临床疗效/安全性Key words
Tongbi capsule/rheumatoid arthritis/syndrome of cold-dampness blocking the channals and collaterals/clinical curative effect/security分类
医药卫生引用本文复制引用
王晓磊,武晔,于笑霞,徐萍,平利峰,孙凤艳,胡丽伟..通痹胶囊治疗类风湿关节炎(寒湿痹阻型)临床疗效及安全性观察[J].天津中医药,2017,34(7):443-445,3.基金项目
河北省中医药管理局项目(2017137). （2017137）
