天津中医药2017，Vol.34Issue(7)：475-477,3.DOI:10.11656/j.issn.1672-1519.2017.07.13
天芪益智颗粒对阿尔茨海默病大鼠学习记忆能力和突触功能的影响
Effects of Tianqi Yizhi granules on learning and memory ability and synaptic function in Alzheimer's disease rats
摘要
Abstract
[Objective] To investigate the effect of Tianqi Yizhi granules on learning and memory ability of the expression of synaptophysin and MAP-2 in Alzheimer's disease rats. [Methods] Alzheimer's disease animal models were built by injecting Aβ1-42 into the lateral ventricle. The 90 SD rats were randomly divided into 6 groups of 15 rats each, which were model group, sham operation group, medicine group (huperzine), low-dose Tianqi Yizhi granules group, medium-dose Tianqi Yizhi granules group, and high-dose Tianqi Yizhi granules group. After continuously administered for 30 days, step through test were used to evaluate the learning and memory skills of the AD rats. Meanwhile, the expression of synaptophysin and MAP-2 in rats' brain were tested by Western Blot. [Results] In the step through test, the latency was increased in the Tianqi Yizhi granules groups compared with the model group (P<0.01), while the error times decreased (P<0.01). In the model group, the expression of synaptophysin and MAP-2 were both down-regulated (P<0.01), and they were both up-regulated in the Tianqi Yizhi granules groups (P<0.01). [Conclusion] Tianqiyizhi granules had improved the ability of learning and memory of Alzheimer's disease rats and it had up-regulated the expressions of synaptophysin and MAP-2 in AD rats' brain, which indicated that Tianqiyizhi granules had a positive influence on the synaptic function in AD rats.关键词
阿尔茨海默病/天芪益智颗粒/突触功能/突触素/微管相关蛋白-2Key words
Alzheimer's disease/Tianqi Yizhi granule/synaptic function/synaptophysin/MAP-2分类
医药卫生引用本文复制引用
刘一川,马涛,王乐,余青,孟繁兴,张允岭..天芪益智颗粒对阿尔茨海默病大鼠学习记忆能力和突触功能的影响[J].天津中医药,2017,34(7):475-477,3.基金项目
国家科技重大专项-重大新药创制项目(2013ZX 09103002-002). （2013ZX 09103002-002）
