天然产物研究与开发2017，Vol.29Issue(6)：917-923,953,8.DOI:10.16333/j.1001-6880.2017.6.003
多球壳菌素延长裂殖酵母细胞寿命可能机制研究
Possible Mechanism for Myriocin-mediated Chronological Lifespan Extension in Fission Yeast Schizosaccharomyce pombe
摘要
Abstract
Looking for anti-aging compounds and studying its action mechanismare the focus and hotspot of aging pharmacology.Previous studies had found that the natural product of myriocin (a sphingolipid synthesis inhibitor) can prolong the lifespan of model organism budding yeast Saccharomyces cerevisiae,while the fission yeast Schizosaccharomycepombe is another modelorganism evolutionarily closer to the mammals,and is significantly different from the budding yeast in morphology and genetics.The effect of myriocin on the lifespan of fission yeast S.pombe was investigated in this study,and the mechanism of myrioin-mediated lifespan regulation was further studied.The results showed that myriocin conservatively prolonged lifespan of fission yeast S.pombe,and mechanisms for myrioin-mediated lifespan extension included enhancing cell stress resistance,accumulation of glycogen and trehalose,reducing intracellular reactive oxygen species.Further studies showed that myriocin-mediated lifespan extension depends on the stress-responsive protein kinase Sty1.In summary,myriocin is a potential anti-aging drug molecule,in future it is expected to be developed into a new drug for the delay of mammalian cells (including humans) aging and prevention and treatment of aging-related diseases.关键词
裂殖酵母/多球壳菌素/时序寿命/衰老/衰老相关疾病Key words
fission yeast/myriocin/chronological lifespan/aging/age-related diseases分类
医药卫生引用本文复制引用
高杰,朱荣,黄新河..多球壳菌素延长裂殖酵母细胞寿命可能机制研究[J].天然产物研究与开发,2017,29(6):917-923,953,8.基金项目
四川省科技厅应用基础研究项目(2016JY0113) （2016JY0113）
成都市科技局科技惠民计划(2015-HM01-00047-SF) （2015-HM01-00047-SF）
中央高校基本科研业务费科技创新项目(2682016 CX099) （2682016 CX099）
中国大学生科研训练项目(201510613061) （201510613061）
