天然产物研究与开发2017，Vol.29Issue(6)：1053-1061,9.DOI:10.16333/j.1001-6880.2017.6.026
真菌β-葡萄糖苷酶在转化人参皂苷单体中的应用进展
Review on Conversion of Ginsenoside by Fungial β-D-Glucosidase
摘要
Abstract
Ginsenosides,the main pharmacologically active natural compounds in ginseng (Panax ginseng),have multiple medical effects such as anti-oxidative,anti-cancer,antiaging and other health-improving activities.Rh2 and Rg3 are rare ginsenosides which represent promising candidates for cancer prevention and therapy and have low toxicity.Recent research showed that β-D-glucosidase from fungi can convert major ginsenosides into rare ginsenosides via the hydrolyses of glucoside.In this review,the pathway of biosynthesizing ginsenosides,anti-cancer activities of different classes of ginsenosides were summarized and recent works on functional characterization of β-D-glucosidase were highlighted.These breakthroughs provided an inexpensive and efficient industrial platform for the manufacture of ginsenosides for clinical applications.关键词
人参皂苷/β-葡萄糖苷酶/真菌/糖基修饰Key words
ginsenoside/β-D-glucosidase/fungi/glycosylation modification分类
农业科技引用本文复制引用
朱大伟,王宇,李玉花..真菌β-葡萄糖苷酶在转化人参皂苷单体中的应用进展[J].天然产物研究与开发,2017,29(6):1053-1061,9.基金项目
中央高校基本科研业务费专项(2572016BA06) （2572016BA06）
黑龙江省应用技术研究与开发计划(GY2016ZB0097) （GY2016ZB0097）
国家林业局948项目(20144-60) （20144-60）
