西安交通大学学报（医学版）2017，Vol.38Issue(3)：326-331,6.DOI:10.7652/jdyxb201703002
妇女围孕期特殊危险因素暴露对新生儿出生缺陷的影响
Association between birth defects and special risk exposures during peri-conception period
摘要
Abstract
Objective To analyze the effect of special risk exposures during periconception period on birth defects of newborns.Methods From Jul.to Dec.2013,the multi-stage stratified random sampling method was adopted.Women of childbearing age between 15 and 49 who were pregnant during 2010 to 2013 in Shaanxi Province were selected as study subjects for investigation on special risk factors exposed during periconception period.The Logistic regression model was adopted to analyze the association between newborns' birth defects and special risk exposures.Results The study included 30 010 women of childbearing age and 29 550 newborns with 572 (193.57/ 10 000) cases of birth defects.After adjusting for demographic factors,the risk factors for birth defects were drinking [OR=2.29,95％ CI (1.22,4.29)] and passive smoking [OR=1.25,95％ CI (1.02,1.53)] during periconception.There was a higher risk of birth defects when exposure to medicine [OR =1.64,95％ CI (1.04,2.61)],pesticides [OR =2.41,95％ CI (1.09,5.35)],biological risk factors [OR-1.64,95％ CI (1.05,2.56)],physical risk factors [OR=1.15,95％ CI (1.13,2.34)] and chemical risk factors [OR =2.36,95％ CI (1.36,4.11)] 3 months both before and after pregnancy.Similarly,after adjusting for demographic factors and behaviors,we found that birth defects were related to antibiotics,salicylates,and antitussive,which could increase the risk of birth defects (P＜0.05).Conclusion Exposure to passive smoking and drinking during periconception and exposure to medicines and pesticides,as well as biological,physical and chemical risk factors 3 months before and after pregnancy could increase the risk of birth defects in newborns.关键词
出生缺陷/特殊危险因素暴露/围孕期Key words
birth defect/special risk exposure/peri-conception period分类
医药卫生引用本文复制引用
王红丽,党少农,曾令霞,李强,王全丽,赵亚玲,颜虹..妇女围孕期特殊危险因素暴露对新生儿出生缺陷的影响[J].西安交通大学学报（医学版）,2017,38(3):326-331,6.基金项目
国家自然科学基金资助(No.81230016)和陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)Supported by the National Natural Science Foundation of China (No.81230016) and the Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning (No.sxwsjswzfcght2016-013) （No.81230016）
